Patro, G., Panda, M., Das, P., Bhaiji, A., Panda, A., Sahoo, H. (2016). Pharmacological evaluation of (Linn.) on bronchial asthma. test, 15(1), 25-30. doi: 10.4103/1687-4315.184030
Ganesh Patro; Madhulata Panda; Prativa Das; Amrita Bhaiji; Avinash Panda; Himanshu Bhusan Sahoo. "Pharmacological evaluation of (Linn.) on bronchial asthma". test, 15, 1, 2016, 25-30. doi: 10.4103/1687-4315.184030
Patro, G., Panda, M., Das, P., Bhaiji, A., Panda, A., Sahoo, H. (2016). 'Pharmacological evaluation of (Linn.) on bronchial asthma', test, 15(1), pp. 25-30. doi: 10.4103/1687-4315.184030
Patro, G., Panda, M., Das, P., Bhaiji, A., Panda, A., Sahoo, H. Pharmacological evaluation of (Linn.) on bronchial asthma. test, 2016; 15(1): 25-30. doi: 10.4103/1687-4315.184030

Pharmacological evaluation of (Linn.) on bronchial asthma

Egyptian Pharmaceutical Journal
Volume 15, Issue 1, January 2016, Pages 25-30    PDF (407 K)
DOI: 10.4103/1687-4315.184030
Authors
Ganesh Patro; Madhulata Panda; Prativa Das; Amrita Bhaiji; Avinash Panda; Himanshu Bhusan Sahoo
Abstract
Objective
The present study was conducted to investigate the antiasthmatic potential from the flowers of Linn. to validate its traditional claims.
Materials and methods
The antiasthmatic activity of the hydroalcoholic extract of flower (HMPF) was evaluated by studying histamine or acetylcholine-induced bronchospasm in guinea pigs, compound 48/80-induced mast cell degranulation in albino rats, and histamine-induced constriction in isolated guinea pig trachea. The preconvulsion dyspnea time at the 0th and seventh day at a dose of 200 and 400 mg/kg in guinea pigs, the percentage of granulated and degranulated mast cells at doses of 500, 750, and 1000 μg/ml in rats, and muscular contraction at doses of 500, 750, and 1000 μg/ml in isolated guinea pig trachea were evaluated and compared with their respective control groups.
Results
Phytochemical studies revealed the presence of flavonoids, steroids, saponin, terpenoids, lignins, and phenolic compounds in the extract. In addition, treatment with HMPF significantly ( < 0.001) decreased the bronchospasm induced by histamine or acetylcholine in guinea pigs, the degranulation of mast cell in rats, and histamine-induced constriction in isolated guinea pig trachea, when compared with the inducer group. In addition, HMPF showed a dose-dependent antiasthmatic effect in the animals.
Conclusion
The present study concluded that the antiasthmatic activity of the HMPF may be due to the presence of the above-mentioned phytoconstituents causing membrane stabilization, suppression of antibody production, and inhibition of antigen-induced histamine and acetylcholine.
Keywords
Asthma; bronchospasm; histamine; mast cell degranulation
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