Development and evaluation of nanosized aripiprazole-loaded bioflexy films using a biopolymer from for brain delivery through orosoft palatal mucosal platform | ||
| Egyptian Pharmaceutical Journal | ||
| Volume 16, Issue 1, January 2017, Pages 62-68 PDF (348.3 K) | ||
| DOI: 10.4103/1687-4315.205832 | ||
| Authors | ||
| N.V. Satheesh Madhav; Vishakha Jaiswal; Abhijeet Ojha | ||
| Abstract | ||
| Purpose The National Institute of Mental Health estimated the global cost of mental illness to be $6T by 2030. The purpose of the study was to deliver aripiprazole for brain targeting by suitably designing a bioflexy film for the treatment of different brain disorders. Materials and methods Bioflexy films were prepared by solvent casting technique using aripiprazole as a model drug, different concentrations of isolated biopolymer from , and a standard polymer. Results All formulations of aripiprazole were flexible, smooth, and transparent in nature, with a weight range from 23.73 to 34.48 mg, pH range from 7.27 to 7.39, and folding endurance of 94–116 times. The content uniformity was in the range of 97.2–98.6. Conclusion In-vitro and in-vivo release shows FL2 as the best formulation. On the basis in-vitro and in-vivo drug release, FL2 was found to be best formulation showing mucoadhesivity (36 h), of 2.5 h, of 23.4 h, and having value of 0.9923, best-fit model Higuchi matrix analyzed by BIT-SOFT 1.12. Moreover, it was observed that significant amount of drug reaches to the brain through soft palatal route through neural pathway. | ||
| Keywords | ||
| aripiprazole; biofilm former; bioflexy films; Brain targeting; Lagenaria siceraria | ||
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