Thiothymine in the synthesis of triazolotriazine and hydrazone compounds | ||
| Egyptian Pharmaceutical Journal | ||
| Volume 17, Issue 3, September 2018, Pages 180-189 PDF (552.19 K) | ||
| DOI: 10.4103/epj.epj_17_18 | ||
| Authors | ||
| Hamdi M. Hassaneen; Fatma M. Saleh; Yasmin S. Mohamed; Enas M. Awad | ||
| Abstract | ||
| Background and objectives Fused triazine derivatives are known to be a very important class of compounds that have significant biological activities. Also, they showed a broad spectrum against leukemic cell lines and cancer cells. Our objective after such a study is, on one hand, to shed some light on the synthesis of triazolotriazine and hydrazone derivatives from the thiothymine compound and, on the other hand, to explore the biological activity of the isolated products from such reactions. Materials and methods Reaction of thiothymine and hydrazonoyl chloride in refluxing chloroform in the presence of triethylamine yielded triazolotriazine derivatives . The hydrazino derivative underwent condensation reactions with aldehydes, pyruvic acid, ethyl pyruvate, and ketones to give the corresponding hydrazone derivatives and , respectively. Antimicrobial activities of some newly synthesized compounds were studied using the diffusion plate method. Results and conclusion Both antibacterial and antifungal activities of the new synthesized compounds , , and were studied. Also, the minimum inhibitory concentration values for the highly efficient antibacterial compounds using the most sensitive microorganisms were determined. | ||
| Keywords | ||
| Antimicrobial activities; cycloaddition reaction; hydrazone; Hydrazonoyl halides; thiothymine | ||
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