Antibacterial and phytochemical evaluations of Alternanthera repens (L.) and honey on of clinical origin | ||
| Egyptian Pharmaceutical Journal | ||
| Volume 21, Issue 3, July 2022, Pages 273-281 PDF (875.7 K) | ||
| DOI: 10.4103/epj.epj_10_22 | ||
| Authors | ||
| Olorunjuwon O. Bello; Faith O. Lebi; Temitope K. Bello; Yinka D. Oluwafemi | ||
| Abstract | ||
| Context Medicinal plants have long been used as a source of therapeutic agents worldwide, and herbal medicines have increasingly been employed in the treatment of diseases. is one of the underexploited plant species for its antimicrobial potentials. Aims This study aimed at investigating the antibacterial efficacy of the leaf and stem ethanolic extracts of and honey against . Materials and methods The phytochemical analyses were performed on ethanolic plant extracts using the universal laboratory techniques for qualitative and quantitative determination. The agar-well diffusion method was used for the in-vitro antibacterial bioassay. The antibacterial activities of the honeys, ethanolic leaf and stem extracts, and antibiotics were compared. The minimum inhibitory concentrations and minimum bactericidal concentrations of the honeys and extracts were determined. Statistical analysis used The students' -test was employed to determine the significant differences between the phytochemical constituents in the extracts and also the antibacterial activities of the ethanolic leaf and stem extracts against . Results Phytochemical screening showed the presence of total phenols, saponins, tannins, total flavonoids, alkaloids, cyanogenic glycosides, phytate, and terpenoids in the plant extracts. The extracts and honeys were able to inhibit the growth of the at varying concentrations (25, 50, 75, and 100%). The combinations of the honeys and ethanolic extracts of the plant parts exerted significantly higher antibacterial effects on . Conclusion The ethanolic extracts of possessed antibacterial properties against , which was more pronounced in combination with honey. The presence of various phytochemicals in the plant indicated its high potential for possible drug production. | ||
| Keywords | ||
| Antimicrobial resistance; Honey; ethanolic extract; Medicinal plant; phytochemicals | ||
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