Sultan, H., Ashry, M., El-Bitar, A., Moustafa, M. (2024). Zeolite intervention counteracts hepato-nephrotoxicity changes and regenerates insulin release in streptozotocin-induced diabetic rats. test, 23(1), 64-72.
Hussein A. Sultan; Mahmoud Ashry; Alaa M.H. El-Bitar; Mohsen A. Moustafa. "Zeolite intervention counteracts hepato-nephrotoxicity changes and regenerates insulin release in streptozotocin-induced diabetic rats". test, 23, 1, 2024, 64-72.
Sultan, H., Ashry, M., El-Bitar, A., Moustafa, M. (2024). 'Zeolite intervention counteracts hepato-nephrotoxicity changes and regenerates insulin release in streptozotocin-induced diabetic rats', test, 23(1), pp. 64-72.
Sultan, H., Ashry, M., El-Bitar, A., Moustafa, M. Zeolite intervention counteracts hepato-nephrotoxicity changes and regenerates insulin release in streptozotocin-induced diabetic rats. test, 2024; 23(1): 64-72.

Zeolite intervention counteracts hepato-nephrotoxicity changes and regenerates insulin release in streptozotocin-induced diabetic rats

Egyptian Pharmaceutical Journal
Volume 23, Issue 1, January 2024, Pages 64-72    PDF (2.11 M)
Authors
Hussein A. Sultan; Mahmoud Ashry; Alaa M.H. El-Bitar; Mohsen A. Moustafa
Abstract
Background and objective
Natural products from various sources tend to be potential candidates for drug discovery. Natural and synthetic zeolites are potentially useful biopharmaceuticals and bio-tools due to their unique and outstanding physical and chemical properties; therefore, this study aimed to estimate the hepatorenal preventive and insulin release restoration efficiencies of zeolite (natural and synthetic) in STZ-induced diabetic rats.
Materials and methods
Post inductions of hyperglycemia with a single (ip) dose of STZ (55 mg/kg), the rats were arranged into four groups (8 rats each): (I) normal control group, (II) STZ-diabetic rats, (III) STZ-diabetic rats treated orally with natural zeolite (300 mg/kg/day), and IV) STZ-diabetic rats treated with synthetic zeolite (300 mg/kg/day).
Results and conclusion
After 6 weeks of treatment of diabetic animals, both zeolite types markedly exhibited antidiabetic, anti-inflammatory, hepato-nephroprotective, and antioxidative stress effects that were monitored from the significant reduction in glucose, ALAT, ASAT, urea, creatinine, MDA, and NO values concomitant with a significant rise in insulin, GSH, SOD and CAT values, close to the corresponding values of normal ones. Also, both zeolites succeeded to modulate STZ-induced histological distortion. In conclusion, both zeolites exhibited multi-health benefits with promising potential against STZ-induced diabetes. This effect may be attributed to the antioxidant and free radical scavenging mechanisms of zeolites that were evidenced by hepatorenal protective activities.
Keywords
antioxidant; diabetes; Hepato-nephrotoxicity; Rats; streptozotocin; Zeolite
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