Assessment of Relevant Hematological and Biochemical Parameters Associated with Toxoplasmosis in Children with Multi-Transfused anemia; β-Thalassemia Major and Sickle Cell Anaemia | ||
| Parasitologists United Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 31 January 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/puj.2025.344090.1280 | ||
| Authors | ||
| Wegdan Mohamed Abd El Wahab* 1; Dalia Saber Morgan2; Doaa Ahmed Hamdy3; Sara Mohamed Foly4; Alaa Aboud5; Yasmin Mohamed2 | ||
| 1Medical Parasitology, Faculty of Medicine, Beni-Suef University, Beni-Suef | ||
| 2Department of Pediatrics, College of Medicine, Beni-Suef University, Egypt. | ||
| 3Department of Medical Parasitology, College of Medicine, Beni-Suef University, Egypt. | ||
| 4Department of Pediatrics, Minia general Hospital, Minia, Egypt. | ||
| 5Department of Tropical Medicine, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt | ||
| Abstract | ||
| Background: Due to frequent blood transfusions and associated immune deficiency, children with β-thalassemia major and sickle cell anemia, are highly exposed to the opportunistic parasite, T. gondii. Notably some biomarkers may reflect the systemic inflammatory response and organ involvement during toxoplasmosis, hence guide the clinical management and treatment strategies. Objective: The study aimed to investigate the detection rate of toxoplasmosis in children with multi-transfused hemolytic anemias and estimate the potential association with relevant hematological and biochemical parameters. Subjects and Methods: In a case control study, 150 anemic children (110 β-thalassemia, and 40 sickle cell anemia), and 150 non-anemic controls were investigated for the positivity of anti-Toxoplasma IgG and IgM antibodies. Complete blood count, serum ferritin, alanine aminotransferase (ALT), aspartate transaminase (AST), urea, creatinine, and C-reactive protein (CRP) were investigated. Results: Respectively the seroprevalence of Toxoplasma IgG (29.3%, and 4%), and IgM (10.7% and 0%) was significantly (P<0.001) higher in anemic children than the controls. Toxoplasma IgG and IgM seropositivity was insignificantly higher in children with β-thalassemia than those with sickle cell anemia. In anemic cases, total leucocytic count, ALT, AST activities, CRP were significantly increased (P≤0.05) in Toxoplasma seropositive than seronegative children. Hemoglobin and other CBC parameters, ferritin, urea and creatinine concentration were stable when compared to seronegative ones. Conclusion: Prior to administering blood transfusion to β-thalassemia major and sickle cell anemia affected children, it is critically necessary to screen donor's blood for anti-T. gondii antibodies. | ||
| Keywords | ||
| β-thalassemia; blood transfusion; CRP; ferritin; kidney functions; liver functions; seroprevalence; sickle cell anemia; toxoplasmosis | ||
|
Statistics Article View: 192 |
||
