Bakry, M., Hassan, N., Mohamed, N., Morsy, M. (2025). Different mechanisms of biofilm formation and regulation by staphylococcus aureus and the new approaches to combat it. test, 29(1.), 57-86. doi: 10.21608/smj.2025.347715.1521
Marwa Mohamed Bakry; Nesma Atef Hassan; Nada Mohamed; Mohanad M Morsy. "Different mechanisms of biofilm formation and regulation by staphylococcus aureus and the new approaches to combat it". test, 29, 1., 2025, 57-86. doi: 10.21608/smj.2025.347715.1521
Bakry, M., Hassan, N., Mohamed, N., Morsy, M. (2025). 'Different mechanisms of biofilm formation and regulation by staphylococcus aureus and the new approaches to combat it', test, 29(1.), pp. 57-86. doi: 10.21608/smj.2025.347715.1521
Bakry, M., Hassan, N., Mohamed, N., Morsy, M. Different mechanisms of biofilm formation and regulation by staphylococcus aureus and the new approaches to combat it. test, 2025; 29(1.): 57-86. doi: 10.21608/smj.2025.347715.1521

Different mechanisms of biofilm formation and regulation by staphylococcus aureus and the new approaches to combat it

Sohag Medical Journal
Volume 29, Issue 1., 2025, Pages 57-86    PDF (1.39 M)
Document Type: Review Article
DOI: 10.21608/smj.2025.347715.1521
Authors
Marwa Mohamed Bakry* 1; Nesma Atef Hassan2; Nada Mohamed3; Mohanad M Morsy4
1Microbiology , Sohag University , Sohag
2Department of Medical Microbiology and Immunology, Faculty of Medicine, Sohag University.
3Department of Medical Microbiology and immunology, Faculty of Medicine, Sohag University
4Intern at faculty of medicine, Sohag university hospitals
Abstract
Staphylococcus aureus can readily form biofilm which enhances the drug-resistance, resulting in life-threatening infections involving different organs. Also the formation of biofilm can protect bacteria from being attacked by the host immune system and antibiotics and thus bacteria can be persistent against external challenges. Biofilm formation occurs due to a series of developmental events including bacterial adhesion, aggregation, biofilm maturation, and dispersion, which are controlled by multiple regulatory systems and lead to hospital acquired infections. Rapidly increasing research and development outcomes on natural products targeting S. aureus biofilm formation and/or regulation led to an emergent application of active phytochemicals and combinations. This review aimed at providing an in-depth understanding of biofilm formation and regulation mechanisms for S. aureus, outlining the most important antibiofilm strategies and potential targets of natural products, and summarizing the latest progress in combating S. aureus biofilm with plant-derived natural products. These findings provided further evidence for novel antibiofilm drugs research and clinical therapies
Keywords
Biofilm; Staphylococcus aureus; Accessory gene regulator genes
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