Elastic vesicles for enhancing the topical repurposed effect of Propranolol against Candida Albicans | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Articles in Press, Accepted Manuscript, Available Online from 04 February 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2025.324207.2293 | ||
| Authors | ||
| Mohammed N. Fenjan* 1; Zaman Kareem Hanan2; Nawras.j. Ka1 | ||
| 1College of Health and Medical Technology, Al-Ayen Iraqi University, AUIQ, Thi-Qar, 64001, Iraq. | ||
| 2College of dentistry University of Thi-Qar | ||
| Abstract | ||
| The goal of this investigation was to load transferosomes with the repurposed antifungal drug propranolol to treat candida albicans topically. The production of transferosomes for enhancing propranolol topical administration was the focus of this study. By a 21.31 full-factorial experiment with different surfactants and phospholipid amounts, transferosomes formulas were fabricated. Transferosomes were assembled by ethanol injection approach. Transferosmes were evaluated for their entrapment efficiency (EE%), particle size (PS), polydispersity index (PDI), and zeta potential (ZP). Employing Design Expert® software, the optimum-formula (F3) was opted, revealing ZP of -28.15±1.11 mV, PDI of 0.476±0.001, PS of 207.05±0.45nm, and EE% of 71.00±0.94%. Further, the optimum formulation illustrated spherical transferosomes with no aggregation under transmission electron microscope inspection. In-vitro release investigation verified that the optimum formula was released in a sustained manner than propranolol solution. In addition, during storage the optimum formula was stable. The histological inspection confirmed the tolerability of the optimum transferosomes. | ||
| Keywords | ||
| Propranolol; candida albicans; factorial design; transferosomes; histopathological study | ||
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