Zidane, A., Mahmoud, E., Hamisa, A., Mokhamer, E. (2025). Molecular and Immunological assessment of anticancer activity of 1,2,4-triazolo[4,3-b] [1,2,4] triazole derivative in combination with Artemisia Judaica Extract in Murine Lung cancer model.. test, 7(1), 60-84. doi: 10.21608/jmals.2025.410693
Abdel Aziz Zidane; Elsayed Abdel Rehem Mahmoud; Amira Hamisa; El-Hassan Mokhamer. "Molecular and Immunological assessment of anticancer activity of 1,2,4-triazolo[4,3-b] [1,2,4] triazole derivative in combination with Artemisia Judaica Extract in Murine Lung cancer model.". test, 7, 1, 2025, 60-84. doi: 10.21608/jmals.2025.410693
Zidane, A., Mahmoud, E., Hamisa, A., Mokhamer, E. (2025). 'Molecular and Immunological assessment of anticancer activity of 1,2,4-triazolo[4,3-b] [1,2,4] triazole derivative in combination with Artemisia Judaica Extract in Murine Lung cancer model.', test, 7(1), pp. 60-84. doi: 10.21608/jmals.2025.410693
Zidane, A., Mahmoud, E., Hamisa, A., Mokhamer, E. Molecular and Immunological assessment of anticancer activity of 1,2,4-triazolo[4,3-b] [1,2,4] triazole derivative in combination with Artemisia Judaica Extract in Murine Lung cancer model.. test, 2025; 7(1): 60-84. doi: 10.21608/jmals.2025.410693

Molecular and Immunological assessment of anticancer activity of 1,2,4-triazolo[4,3-b] [1,2,4] triazole derivative in combination with Artemisia Judaica Extract in Murine Lung cancer model.

Journal of Medical and Life Science
Volume 7, Issue 1, March 2025, Pages 60-84    PDF (2.96 M)
Document Type: Original Article
DOI: 10.21608/jmals.2025.410693
Authors
Abdel Aziz Zidane1; Elsayed Abdel Rehem Mahmoud2; Amira Hamisa1; El-Hassan Mokhamer* 1
1Zoology Department, Faculty of Science, Damanhour University
2Chemistry Department, Faculty of Science, Damanhour University
Abstract
Lung cancer remains a leading cause of cancer-related mortality worldwide, emphasizing the urgent need for innovative therapeutic strategies. This study evaluates the anti-cancer impact of Artemisia Judaica (AJ) and 1,2,4-triazole derivatives (TRI), both individually and in combination, against lung cancer. Immunohistochemical (IHC) analysis revealed significant modulation in the expression of Caspase-3, Caspase-7, and tumor necrosis factor-alpha (TNF-α), indicating enhanced apoptosis and immune responses. Molecular investigations further demonstrated the compounds’ regulatory effects on key oncogenic pathways, specifically EGFR and BRAF. Notably, the combined therapy displayed a synergistic effect, underscoring its potential as a novel therapeutic approach for lung cancer. These findings highlight AJ and 1,2,4-triazole derivatives as promising candidates for further clinical evaluation and development in lung cancer management.
Keywords
lung Cancer; Artemisia Judaica; 1; 2; 4-triazole derivatives; caspase-3; caspase-7; TNF-α
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