Laser-Assisted Drug Delivery in Early Post-Burn Hypertrophic Scars: Review article | ||
| The Egyptian Journal of Plastic and Reconstructive Surgery | ||
| Articles in Press, Accepted Manuscript, Available Online from 09 February 2025 | ||
| Document Type: Review Article | ||
| DOI: 10.21608/ejprs.2025.345952.1396 | ||
| Authors | ||
| Bassel Mohammed Younes* 1; Elsayed Mandour2; Mohammed Soliman Hashish3; Tarek Gamal Shoukr2 | ||
| 1Plastic Surgery Department, Faculty of Medicine, Tanta University | ||
| 2Plastic & Reconstructive Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt | ||
| 3Pediatric Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt | ||
| Abstract | ||
| Hypertrophic scars and keloids arise from an excessive healing process and frequently cause considerable distress to patients. Fractional ablative lasers generate tiny channels in the skin and penetrate scar tissue, prompting a natural regeneration reaction in the damaged areas. Laser-assisted drug delivery (LADD) is a promising therapeutic technique that involves the direct application of drugs that alter scars within the scar tissue via small channels. Burn injuries stem from numerous etiologies, with hot liquids, solids, and flames being the most common culprits. These injuries pose a significant source of morbidity and can impact on a patient's quality of life, psychosocial well-being, and socioeconomic burden. While advances in burn management have reduced mortality rates, they have also led to a growing number of patients experiencing sequelae, notably hypertrophic scars (HTSs). An overly accelerated healing process might result in hypertrophic scars and keloids, which can sometimes cause significant patient issues. One cutting-edge technique for accurately distributing medications under the skin is laser-assisted drug delivery, or LADD. LADD has proven to be quite successful in treating burn injuries and scarring. They enable a speedy recovery, are minimally intrusive, and have a low risk of adverse consequences. Consequently, they are incorporated into certain therapy protocols with other conservative and surgical methods, which can be quite effective but also have a greater likelihood of complications. | ||
| Keywords | ||
| Laser-Assisted Drug Delivery; Post-Burn; Hypertrophic; Scars | ||
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