Ahmed, M., Elhadidy, K., Kamel, M., Mohamed, S., Hamed, A. (2025). Correlation between Insulin Resistance and Thyroid Dysfunction. test, 6(1), 203-216. doi: 10.21608/ejmr.2024.330025.1719
Mahmoud Hassan Ahmed; Khaled Elsayed Elhadidy; Mahmoud Farid Kamel; Sahar Mohamed Mostafa Mohamed; Ahmed Moheyeldien Hamed. "Correlation between Insulin Resistance and Thyroid Dysfunction". test, 6, 1, 2025, 203-216. doi: 10.21608/ejmr.2024.330025.1719
Ahmed, M., Elhadidy, K., Kamel, M., Mohamed, S., Hamed, A. (2025). 'Correlation between Insulin Resistance and Thyroid Dysfunction', test, 6(1), pp. 203-216. doi: 10.21608/ejmr.2024.330025.1719
Ahmed, M., Elhadidy, K., Kamel, M., Mohamed, S., Hamed, A. Correlation between Insulin Resistance and Thyroid Dysfunction. test, 2025; 6(1): 203-216. doi: 10.21608/ejmr.2024.330025.1719

Correlation between Insulin Resistance and Thyroid Dysfunction

Egyptian Journal of Medical Research
Volume 6, Issue 1, January 2025, Pages 203-216    PDF (655.51 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2024.330025.1719
Authors
Mahmoud Hassan Ahmed1; Khaled Elsayed Elhadidy1; Mahmoud Farid Kamel1; Sahar Mohamed Mostafa Mohamed2; Ahmed Moheyeldien Hamed* 1
1Internal Medicine Department, Faculty of medicine, Beni-Suef University
2Medical biochemistry and molecular biology Department, Faculty of medicine, Beni-Suef University
Abstract
Background: Thyroid hormones T3 and T4 maintain a fine balance of glucose homeostasis by acting as insulin agonistic and antagonistic. Objective: In this study we aim to asses insulin resistance in patients who have thyroid disorders. Methods:  the current inquiry was a case-control study with 60 participants. The subjects were split into three equal groups: 20 individuals with a hypothyroidism, 20 individuals with hyperthyroidism and
20 euthyroid individuals. Gathering medical history and measure body mass index. In addition, check the thyroid gland locally. Testing for HOMA-IR, TSH, Free T3, and Free T4 .Results: There was a statistically significant moderate negative linear correlation between free T4 and HOMA-IR (r=-0.491, p=0.028) only in hypothyroid patients' group. There was a statistically significant moderate negative linear correlation between free T3 and HOMA-IR (r=-0.505, p<0.001) in all studied population, however this significant correlation lost in studying each group separately (p-values >0.05). There was a statistically significant moderate positive linear correlation between TSH and  HOMA-IR (r=0.644, p<0.001) in all studied population, however this significant correlation lost in studying each group separately (p-values >0.05). Conclusion: There is a significant association between thyroid dysfunction and HOMA-IR.
Keywords
Thyroid; Insulin Resistance; HOMA-IR
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