Impact of Sperm Telomere Length on Sperm Quality and Male Fertility | ||
| The Medical Journal of Cairo University | ||
| Volume 92, Issue 12, December 2024, Pages 1059-1066 PDF (172.54 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcu.2024.411332 | ||
| Author | ||
| ABDELRAHMAN A. ABDELRAHMAN, Ph.D.1; DINA SAMEER, M.Sc.2; MANAL EL-HAMSHARY, Ph.D.3; MEDHAT HASHEM, Ph.D.4 and OMAIMA. KHAMISS, Ph.D.5 | ||
| 1Molecular Diagnostics and Therapeutics, Genetic Engineering and Biotechnology Institute, University of Sadat City (GEBRI-USC), 2In Vitro Fertilization (IVF) Unit, Faculty of Medicine, Cairo University, M.Sc. Reproduction Technologies Genetic Engineering and Biotechnology Institute, University of Sadat City (GEBRI-USC), 3Human Molecular Diagnostics, Genetic Engineering and Biotechnology Institute, University of Sadat City (GEBRI-USC), 4Animal Biotechnology Department Genetic Engineering and Biotechnology Institute, University of Sadat City (GEBRI-USC) and 5Cell Culture and Molecular Virology, Animal Biotechnology Department, Genetic Engineering and Biotechnology Institute, University of Sadat City (GEBRI-USC) | ||
| Abstract | ||
| Abstract Background: Telomeres are specialized chromatin struc-tures found at the ends of eukaryotic chromosomes; their length is an important factor in the early stages of embryonic develop-ment in humans. While studies have shown that different sperm preparation methods affect concentration, motility, and mor-phology, little is known about the probable association between telomere length and sperm preparation methods. Aim of Study: The purpose of this research was to exam-ine the comparison of a raw sample with a sample prepared by gradient. Material and Methods: Thirty semen samples were ob-tained from thirty patients for this prospective cohort study. From January 2021 to October 2021, participants admitted to the Obstetrics and Gynecology Department, in vitro fertiliza-tion (IVF) unit, Faculty of Medicine, Cairo University, were evaluated. Following clearance from Cairo University’s Local Ethical Committee. Gradient was approved to select sperm with longer telomere length. Results: STL is positively associated with progressive sperm motility. Conclusion: Thus, the use of assisted reproductive technol-ogies to choose sperm with longer telomeres boosts the success rate of pregnancies and births, which in turn enhances the prog-eny’s longevity. | ||
| Keywords | ||
| Reproductive technology; Density gradient cen-trifugation; Infertility; Sperm; telomere length | ||
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