Chitosan: A Multifunctional Biopolymer for Enhanced Wound Healing with Antimicrobial, Haemostatic, and Analgesic Properties, Supported by Clinical Evidence | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Articles in Press, Accepted Manuscript, Available Online from 12 February 2025 | ||
| Document Type: Review Article | ||
| DOI: 10.21608/bfsa.2025.336354.2345 | ||
| Authors | ||
| Khaled Elsayed Abuelella* 1; Mohamed Adel Fakher2; Hassan Gamal Mostafa1; Omar Mohamed ElRakabawy3 | ||
| 1Pharmaceutics Department, Faculty of Pharmacy, O6U | ||
| 2Pharmaceutics Department, Faculty of pharmacy, Tanta University | ||
| 3Clinical Pharmacy Department, Faculty of Pharmacy, O6U | ||
| Abstract | ||
| Wound healing is a complex physiological process that repairs tissue integrity with stages including hemostasis, inflammation, proliferation, and remodeling. The primary aim of wound management is to avert infection, limit necrotic tissue development, expedite the healing process, and reduce scar formation. Chitosan (CS) is a biopolymer that has been extensively studied for its potential use in wound healing applications. This is due to its biocompatibility, biodegradability, non-toxicity, antimicrobial, haemostatic, and analgesic properties. Protection against bacteria, algae, and fungi is the source of its antimicrobial properties. Chemical modifications have improved the haemostatic activity and analgesic properties of the CS, which enhance patient comfort during the recovery phase. Furthermore, CS and its derivative have attracted much attention due to the accelerated wound healing. This review examines the synthesis, structural characteristics, and inherent properties of CS, as well as its potential applications in wound treatment, with a focus on antimicrobial efficacy, haemostatic capabilities, analgesic effects, and relevant clinical studies. | ||
| Keywords | ||
| Keywords: Chitosan; Antimicrobial; Wound healing; Hemostatic; Clinical studies | ||
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