Effect of Chromium and Cadmium on Genetic and Oxidative Stress mechanisms in Bladder Cancer Patients | ||
| Mansoura Journal of Chemistry | ||
| Volume 59, Issue 1, January 2023, Pages 19-24 PDF (768.16 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcc.2023.411521 | ||
| Abstract | ||
| Background: Heavy metals toxicity has been linked to cancer progression. The relation between some metal ions and bladder cancer (BC) has been elucidated in previous studies. But the influence of these metals on bladder carcinogenesis still needs further study. Methods and results: This study includes25 BC patients. Chromium and cadmium levels, markers of oxidative stress and m-RNA of IL-6 and Bax were detected in tissues obtained from BC patients. Cr and Cd levels were highly expressed in tumor tissues than normal. The concentration of Malondialdehyde (MDA) was highly detected in tumor tissues, while Superoxide dismutase (SOD) level was lower. IL-6 was up-regulated in tumor tissues than in normal tissues while Bax level was down regulated in tumor tissue. In cancer tissue, there were significant correlations between Cd level with Bax (Bcl-2 Associated X-protein) and IL-6 gene expression. Conclusions: The correlation between Cd and Bax and IL-6 gene expression may indicate the carcinogenic role of Cd in bladder cancer patients | ||
| Keywords | ||
| Bladder cancer; Chromium; Cadmium; Oxidative stress; Gene expression | ||
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