L-carnitine promising effects in cisplatin-induced nephrotoxicity | ||
| Mansoura Journal of Chemistry | ||
| Volume 59, Issue 1, January 2023, Pages 46-50 PDF (846.95 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcc.2023.411529 | ||
| Abstract | ||
| Objective: This study aimed at exploring the therapeutic efficacy of L-Carnitine (LC) against cisplatin-induced nephrotoxicity (CIN) by assessing oxidative stress response, and relevant gene expression in rat kidney tissues. Methods: Rat CIN model was induced by intraperitoneal injection of Cisplatin (Cis). Eighteen male Sprague-Dawley mature rats with age (6 weeks) weighing 180 ± 20 gm were randomized to receive either control (saline), Cis or Cis + LC. Markers of oxidative stress (superoxide dismutase (SOD) and Malonaldehyde (MDA) and Bax and BCL-2 gene expression profiles were assessed thereafter. Results: Cisplatin administration showed a marked increase in oxidative stress as evidenced by elevated MDA and diminished SOD levels, and changes in gene expressions of apoptosis-regulating genes (BCL2, BAX). Remarkably, treatment with LC normalized most parameters and achieving gene expression levels comparable to control groups. Conclusion: Our findings highlight the significant nephroprotective potential of LC against CIN, pivoting the way for bigger clinical studies and incorporation into clinical care guidelines. | ||
| Keywords | ||
| Cisplatin; Nephrotoxicity; L-Carnitine; Oxidative stress; Gene expression; BCL-2; Bax; SOD; MDA | ||
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