Azurocidin and CXCL9 as Novel Biomarkers in Women with Asymptomatic Bacteriuria | ||
| Egyptian Journal of Medical Microbiology | ||
| Volume 34, Issue 3, July 2025 | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.361250.1485 | ||
| Authors | ||
| Ola A.A. Alkhirsan; ِAhmed A.J. Aljanaby* | ||
| Department of Biology, Faculty of Science, University of Kufa, Iraq | ||
| Abstract | ||
| Background: Azurocidin and CXCL9 are two important proteins that play crucial roles in the immune response during urinary tract infections. Objective: This study aims to investigate the immunological role of azurocidin and CXCL9 in women with acute (symptomatic) and chronic (asymptomatic) urinary tract infections. Methodology: The study included 35 healthy women as controls, 35 women complain of acute UTIs, and 35 women of chronic UTIs who were hospitalized in ALNajaf Hospital between 1st June 2024 and the end of January 2025. All women have been diagnosed by a physician. We have used ELISA to assess azurocidin and CXCL9 level in each woman's serum. Results: The results proved that there was a significant increase (P value<0.0001) in serum levels of Azurocidin in women with acute UTIs (19.13 ± 2.834 pg/ml) and chronic UTIs (28.78 ± 4.320 pg/ml) compared with control (7.075 ± 0.6675 pg/ml). The serum levels of Azurocidin in women with chronic UTIs were substantially higher (P value<0.0001) than those infected acute UTIs. The results demonstrated that there was a significant increase (P value<0.0001) in serum levels of CXCL9 in women with acute UTIs (401.1 ± 60.28 pg/ml) and chronic UTIs (541.2 ± 48.18 pg/ml) compared with control (240.5 ± 12.01 pg/ml). Conclusion: Our findings show that azurocidin and CXCL9 have a crucial immunological role in women suffering from acute or chronic UTIs; these markers might be helpful for new diagnosis in women with undiagnosed chronic UTIs. | ||
| Keywords | ||
| Azurocidin; CXCL9; Women; Acute; Chronic | ||
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