Mohamed, A., Mohamed, A., Zahran, A., Gad, A., Mekky, A. (2025). Antimicrobial, anti-inflammatory, anticancer and antiviral activity of bioactive compounds from Pseudomonas aeruginosa isolated from Mediterranean Sea, Alexandria, Egypt. test, 10(1), 123-134. doi: 10.21608/mb.2025.322359.1173
Abdelraheem N. Mohamed; Abdel Kareem S.H. Mohamed; Asmaa M. Zahran; Ahmed Mohamed Gad; Alsayed E. Mekky. "Antimicrobial, anti-inflammatory, anticancer and antiviral activity of bioactive compounds from Pseudomonas aeruginosa isolated from Mediterranean Sea, Alexandria, Egypt". test, 10, 1, 2025, 123-134. doi: 10.21608/mb.2025.322359.1173
Mohamed, A., Mohamed, A., Zahran, A., Gad, A., Mekky, A. (2025). 'Antimicrobial, anti-inflammatory, anticancer and antiviral activity of bioactive compounds from Pseudomonas aeruginosa isolated from Mediterranean Sea, Alexandria, Egypt', test, 10(1), pp. 123-134. doi: 10.21608/mb.2025.322359.1173
Mohamed, A., Mohamed, A., Zahran, A., Gad, A., Mekky, A. Antimicrobial, anti-inflammatory, anticancer and antiviral activity of bioactive compounds from Pseudomonas aeruginosa isolated from Mediterranean Sea, Alexandria, Egypt. test, 2025; 10(1): 123-134. doi: 10.21608/mb.2025.322359.1173

Antimicrobial, anti-inflammatory, anticancer and antiviral activity of bioactive compounds from Pseudomonas aeruginosa isolated from Mediterranean Sea, Alexandria, Egypt

Microbial Biosystems
Volume 10, Issue 1, March 2025, Pages 123-134    PDF (1015.15 K)
Document Type: Original Article
DOI: 10.21608/mb.2025.322359.1173
Authors
Abdelraheem N. Mohamed1; Abdel Kareem S.H. Mohamed2; Asmaa M. Zahran3; Ahmed Mohamed Gad4; Alsayed E. Mekky* 5
1South Egypt Cancer Institute, Assiut University, Assiut 71111, Egypt.
2Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Assiut 71111, Egypt.
3Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut 71111, Egypt.
4National institute of Oceanography and Fisheries (NIOF), Qayed Bay, Anfoushy, Alexandria 21556, Egypt.
5Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt.
Abstract
In this study, four seawater and sediment samples were collected, Marine Pseudomonas aeruginosa (K3) was isolated from Alexandria, Egypt, and identified by using 16S rRNA gene sequencing and biochemical analyses. Optimization was carried out with various parameters to determine the optimum conditions to produce bio active compounds.   Pseudomonas aeruginosa k3 is known for producing bioactive compounds that are effective against a variety of pathogenic microorganisms, including Staphylococcus aureus (ATCC25923), Escherichia coli (ATCC 8739), Bacillus subtilis (ATCC 6633), Klebsiella pneumonia (ATCC 13883), Enterococcus faecalis (ATCC29212), Vibrio fluvialis (ATCC33809), and Pseudomonas aeruginosa (ATCC9027). GC-MS chromatography was used to identify the bioactive components. Additionally, we investigated the antiviral (HAV and CoxB4), anti-inflammatory (HRBC hemolysis and membrane stabilization), and anticancer (HepG2, Vero, and MCF-7) activity.
Keywords
Antioxidant activity; bioactive metabolites; cytotoxicity; drug discovery; marine bacteria; secondary metabolites
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