Platelet Parameters and Red Cell Distribution Width as Diagnostic Markers for Early Diagnosis of Neonatal Sepsis. A Prospective Comparative study | ||
| Annals of Neonatology | ||
| Articles in Press, Accepted Manuscript, Available Online from 09 March 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/anj.2025.360024.1108 | ||
| Authors | ||
| Amira Mousa Abdelfattah* 1; Ahlam Mohamed Ismail1; Madiha Abdallah Sayed1; Emad Allam Abdelnaem2 | ||
| 1Pediatric Department - Faculty of Medicine - Minia University - Egypt | ||
| 2Clinical Pathology Department - Faculty of Medicine - Minia University - Egypt, | ||
| Abstract | ||
| Background: Early identification of neonatal sepsis improves the outcomes. Therefore, identifying new diagnostic tests for newborn sepsis is crucial. Aim: This study aimed to determine total platelet count (TPC), mean platelet volume (MPV), MPV/TPC ratio, platelet distribution width (PDW), and red cell distribution width (RDW) in neonates with sepsis and to evaluate their potential as early diagnostic indicators of newborn sepsis in NICU. Methods: This one-year prospective comparative study was conducted in the neonatal intensive care unit (NICU). The study included 100 neonates, aged 28 to38 weeks gestational age and within the first 28 days of life. Participants were divided into two groups: Group I (septic group), comprising 50 neonates exhibiting signs and symptoms suggestive of sepsis or with risk factors for sepsis; and Group II (control group), comprising 50 clinically stable neonates without risk factors for sepsis. All neonates underwent sepsis screening and clinical assessment. Results: Significant variations were observed in the mean TPC, MPV, MPV/TPC ratio, PDW, and RDW between the septic and non-septic groups. The sensitivity and specificity values were as follows: TPC (cut-off <208.5×10³/µL), 84% and 88%; MPV (cut-off <9.95 fL), 80% and 88%; MPV/TPC (cut-off <0.065), 82% and 88%; PDW (cut-off <208.5), 84% and 88%; and RDW (cut-off <14.25%), 84% and 82%, respectively. All the parameters have a significant p-value <0.001 Conclusions: Platelet parameters total platelet count (TPC), mean platelet volume (MPV), MPV/TPC ratio, platelet distribution width (PDW) and red cell distribution width (RDW) can be cosidered early markers for detection and diagnosis of neonatal sepsis | ||
| Keywords | ||
| Sepsis; Gestational age; Platelet parameters; Neonatal intensive care unit (NICU) | ||
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