Protective impact of Hesperidin in hyperthyroid-induced Cardiomyopathy in rats | ||
| Medicine Updates | ||
| Articles in Press, Accepted Manuscript, Available Online from 16 March 2025 PDF (1.27 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/muj.2025.366265.1211 | ||
| Authors | ||
| Suzan A Khodir* 1; Noha Abd El-aziz2; Reem M Emam3; Heba Ashraf Elmalky4; Mai M Abdalraouf5; Mohamed Awad Shahien6; Reem Mohammed Ahmed7; Tarek H Abd-Elhamid8; Rasha Arafa Abd Elmaksoud9; Shorouk E. M. Elmorshdy3 | ||
| 1Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt. | ||
| 2Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||
| 3Medical Physiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||
| 4Endocrinology unit, Internal Medicine Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||
| 5Cardiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||
| 6Clinical Pharmacology Department, Faculty of medicine, Damitta University, Egypt | ||
| 7Medical Biochemistry and Molecular Biology Department Faculty of Medicine (Girls), Al-Azhar University | ||
| 8Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt. Histology, Faculty of Medicine, Aqaba Medical Sciences University, Aqaba, 77110, Jordan | ||
| 9Pathology Department, Faculty of Medicine, PortSaid University, Egypt. | ||
| Abstract | ||
| Background: Higher risk of cardiovascular problems is linked to hyperthyroidism. The citrus bioflavonoid hesperidin (HSP) has cardioprotective, anti-inflammatory, and antioxidant impacts. Aim of the study: to illustrate the possible underlying processes and cardioprotective impact of HSP in cardiomyopathy caused by hyperthyroidism. Material and methods: Thirty male albino rats were split into three groups: Hyperthyroid, Hyperthyroid+HSP, and control (10/group). After four weeks rats were subjected to ECG evaluation, LVW/ tibial length, Serum TSH, Serum total T3, T4, Serum LDH, Serum CK-MB, Cardiac MDA, Cardiac SOD, Cardiac TNF-α, Cardiac IL-6, Cardiac genes expression of ANF, Caspase-3 and NF-kB evaluation. Furthermore, cardiac histological and immunohistochemical analyses were performed. Results: There was dramatically elevated heart rate, LVW/ tibial length, serum tT3, serum tT4, serum LDH, serum CK-MB, cardiac MDA, cardiac TNF-α, cardiac IL-6, cardiac ANF gene expression, cardiac Caspase-3 gene expression and cardiac NF-kB gene expression alongside a marked reduction in duration of PR interval and QT interval, serum TSH and cardiac SOD of hyperthyroid group compared to control. HSP dramatically ameliorated hyperthyroid-induced cardiac alterations generated by hyperthyroidism. Conclusion: In hyperthyroid-induced cardiomyopathy, HSP has a cardioprotective effect by enhancing ANF levels and regulating the heart's anti-inflammatory, anti-apoptotic, and antioxidant mechanisms. | ||
| Keywords | ||
| ANF; Cardiomyopathy; Hesperidin; Hyperthyroid; NF-kB | ||
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