Retrospective Epidemiological Study of Pediatric Primary Central Nervous System Tumors in Mansoura University Hospital. | ||
| SECI Oncology Journal | ||
| Volume 13, Issue 1, January 2025, Pages 84-93 PDF (368.03 K) | ||
| Abstract | ||
| Background: Central nervous system (CNS) tumors are the second most common malignancy in children after leukemia and lymphoma combined. They account for 26% of all pediatric tumors and are the leading cause of cancer- related death in children. Advances in management have led to better survival. Methods: A total of 62 patients with primary CNS tumors who attended the Clinical Oncology and Nuclear Medicine Department, Mansoura University, from the first of January 2012 to 31 March 2020 were evaluated retrospectively. To assess their prognostic significance, all factors were correlated with overall survival (OS) and progression-free survival (PFS). Results: The median OS was 105 months. The 1,2, 5, and 7-year OS were 80.7%, 63.7%, 59.9%, and 55.1% respectively. Univariate analysis revealed that metastatic disease at diagnosis (p = 0.029) and radiotherapy site (p = 0.02) were statistically significant factors influencing OS. However, in multivariate analysis, metastatic disease at diagnosis remained the only significant predictor of OS (p = 0.042). The median PFS was 86.08 months. The 1,2, 5, and 7-year PFS were 72.7%, 65.3%, 60.3%, and 52.8% respectively. The univariate analysis of PFS revealed statistically significant associations with gender (P=0.047), chemotherapy (0.041), and radiotherapy site (0.02), while in multivariate analysis, the radiotherapy site remained the only significant predictor for PFS. Conclusion: Our study provides epidemiological insights into pediatric CNS tumors. Further prospective studies focusing on various pathological CNS tumor subtypes with larger sample sizes are encouraged. | ||
| Keywords | ||
| Pediatric CNS tumors; epidemiology; progression-free survival; overall survival | ||
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