Immunohistochemical Expression of GLUT-1 in Endometrial Hyperplasia and Carcinoma | ||
| Aswan University Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 26 March 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aumj.2025.359156.1190 | ||
| Authors | ||
| Rasha Mohamed Samir Sayed1; Eman M S Muhammed2; Hagar H A Oraby* 1; Shaimaa M M Bebars3 | ||
| 1department of pathology, faculty of medicine | ||
| 2Pathology Department Faculty of medicine Sohag university | ||
| 3Pathology Department, Faculty of Medicine, Aswan University | ||
| Abstract | ||
| Early detection of endometrial carcinoma (EC), especially its precursor lesions, is crucial for reducing mortality but remains challenging. Immunohistochemistry (IHC), as a diagnostic or prognostic, method maybe helpful in this conflict. Glucose transporter-1 (GLUT-1) has emerged as a promising biomarker for cancer development. This study aimed to distinguish between atypical endometrial hyperplasia/ endometrioid intraepithelial neoplasia (AEH/EIN) in comparable to endometrial hyperplasia (EH) without atypia based on the percentage of stained cells and staining intensity. Additionally, the study examined the relationship between GLUT-1 expression and clinicopathological factors linked to prognosis in EC cases. Endometrial tissue was immunostained with antibody against GLUT-1. Results: A significant upward association was observed between GLUT-1 expression and disease progression from EH without atypia to EC. In EH without atypia, 33.3% of cases demonstrated weak GLUT-1 expression, whereas, among EH with atypia, 38.5% exhibited strong GLUT-1 expression, and 61.5% showed moderate expression. All cases of EC displayed strong GLUT-1 expression. GLUT-1 expression was positively correlated with increasing tumor grade and stage. Conclusions: GLUT-1 expression was increased progressively with disease progression from EH to EC and with higher grades and stages of EC. | ||
| Keywords | ||
| Endometrial hyperplasia; endometrial carcinoma; IHC GLUT-1 expression | ||
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