Urine Cofilin-1 As An Early Predictor For Type 1 Cardio renal Syndrome in the Coronary Care Unit | ||
| Zagazig University Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 27 March 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2025.365210.3860 | ||
| Authors | ||
| Ahmed Mohamed Abd-el-Rahim Abd-el-Kader* 1; Mabrouk Ibrahim Ismail2; Walid Afify2; Nafesa Mohammed Kamal2; Hanan Abdelsalam Ali Samour2; Fatima Al Taher Taha Morsi2 | ||
| 11Internal Medicine Department, Al-Ahrar Teaching Hospital, General Organization for Teaching Hospitals and Institutes (GOTHI), Egypt | ||
| 2Internal Medicine & Nephrology Department, Faculty of Medicine - Zagazig University | ||
| Abstract | ||
| Background: Patients with acute decompensated heart failure (ADHF) may experience major consequences from type 1 cardio renal syndrome (CRS), which can have a major impact on HF patients. Urine Cofilin-1 measured by the gold nanoparticle-based immunoassay LSPCFB could be used as a single biomarker for CRS prediction in patients in critical care units. So we aimed to evaluate performance of urine cofilin-1 as a predictor for type 1 Cardio renal Syndrome patients using Gold Nanoparticle- and Laser-Based Approach in coronary care unit. Methods: A case-control study was conducted on 60 subjects admitted to the Coronary Care Unit (CCU). Participants were divided into four groups based on heart and renal function status. Urine Cofilin-1 levels were measured using ELISA and LSPCFB. Patients were monitored for 7 days to confirm CRS development based on KDIGO criteria. Results: Urine Cofilin-1 levels were significantly elevated in CRS patients compared to other groups. The LSPCFB method showed superior specificity and overall diagnostic accuracy (AUC = 0.678) compared to ELISA. Correlations were observed between Cofilin-1 levels and several renal and cardiac function parameters. LSPCFB showed higher diagnostic performance, with an optimal cutoff of ≥0.3 and acceptable sensitivity (73.3%) and specificity (70%). Conclusion: Urine Cofilin-1 is a promising early biomarker for detecting Type 1 CRS, especially when measured using the LSPCFB technique. | ||
| Keywords | ||
| Heart Failure; Cardio-Renal Syndrome; type 1 urine cofilin; AKI | ||
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