Persistent Pulmonary Hypertension in Neonates: Insights from Echocardiography | ||
| Zagazig University Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 29 March 2025 | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/zumj.2025.370515.3890 | ||
| Authors | ||
| Besheir Abdallah Hassan1; Hanan Samir Ahmed2; Samar Mossad Hassan Elgohary* 3; Marwa Lotfy Mohammed Rashad1 | ||
| 1Pediatrics Department, Faculty of Medicine, Zagazig University, Egypt | ||
| 2Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt | ||
| 3Pediatrics Department, Zifta General Hospital, Egypt | ||
| Abstract | ||
| Background: A serious clinical issue known as persistent pulmonary hypertension of the newborn (PPHN) is typified by severe and refractory hypoxemia brought on by increased pulmonary vascular resistance, which causes deoxygenated blood to be shunted from the right to the left extrapulmonaryly. Infants with severe PPHN have a significant early death rate and are linked to a variety of cardiopulmonary diseases. Infants with PPHN who survive are more likely to experience long-term complications. The physiology of PPHN can be divided into three categories: (1) maladaptation, where pulmonary vessels have normal numbers and structures but exhibit abnormal vasoreactivity; (2) excessive muscularization, where smooth muscle cells are thicker and muscles extend farther to vessels that are typically not muscularized; and (3) underdevelopment, where pulmonary hypoplasia is linked to fewer pulmonary arteries. PPHN is diagnosed by trained neonatal intensivists using bedside structural and functional echocardiography, even though the diagnosis is initially prompted by clinical signs like respiratory or hemodynamic instability in a typical setting (like the ones listed above). Conclusion: it is beneficial to diagnose PPHN, rule out any underlying congenital cardiac defects (such transposition of the great arteries or total abnormal pulmonary venous return), and then evaluate the hemodynamic condition (hypovolemic or obstructive shock). | ||
| Keywords | ||
| Persistent pulmonary hypertension; neonates; echocardiography | ||
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