Association of osteopontin promoter polymorphism and aggresivness in breast cancer | ||
| Sohag Medical Journal | ||
| Article 53, Volume 22, Issue 1, January 2018, Pages 375-379 PDF (76.82 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/smj.2018.42049 | ||
| Authors | ||
| Madeha M. Zakhary1; Aida A. Mahmoud2; Wael B. Ahmed3; Marwa shaaban Hashim4 | ||
| 1Department, of Medical Biochemistry, Faculty of Medicine, Assuit university. | ||
| 2Department, of Medical Biochemistry, Faculty of Medicine, Sohag university. | ||
| 3Department of General Surgery, Faculty of Medicine, Sohag university. | ||
| 4Department of Biochemistry and microbiology, Facaulty of Medicine, Sohag University. | ||
| Abstract | ||
| Osteopontin (OPN) is an extracellularmatrix protein that is overexpressed in various cancers and promotes oncogenic features including cell proliferation, survival, migration, and angiogenesis, among others. OPN can participate in the regulation of the tumor microenvironment, affecting both cancer and neighboring cells. Here, we review The role of single-nucleotide polymorphism (SNP)-443 of the OPN gene in cancer aggressiveness. | ||
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