Efficacy of Cabergoline Combined with Letrozole Versus Letrozole Alone in Anovulatory Pco Women with Europrolactinaemia, Randomized Controlled Trial | ||
| Evidence Based Women's Health Journal | ||
| Volume 15, Issue 15, January 2025, Pages 1-6 PDF (327.2 K) | ||
| Document Type: Research High lights | ||
| DOI: 10.21608/ebwhj.2024.310047.1344 | ||
| Author | ||
| Mervat Mohamed Harira* | ||
| Obstetrics and gynaecology department zagazig university Egypt | ||
| Abstract | ||
| Objective: To evaluate the therapeutic effect of adding cabergoline with letrozole in infertile women having (PCOS) with normal prolactin level. Study design: A randomized controlled study. Patients & methods: Infertile PCOS women with normal prolactin level attending out patient clinic of obstetric &gynaecology department of zagazig university & private clinic . Those included( 200 ) patients randomly divided into two groups, each group(100) patients group A,received letrozole plus cabergoline and group B recieved letrozole. Study design: for all patients , ultrasound on 2 nd day of cycle then folliculometry after treatment detecting number,size of follicles ≥17mm with endometrial thickness ,patients followed for one cycle. The primary outcome was ovulation rate. The secondary outcomes, clinical pregnancy r, miscarriage , multiple pregnancy and ovarian hyperstimulation rate. Results: 200 patients divided ( 100 in each group ). No statistical difference between both groups in basal criteria. The ovulation rate (group1) was 75% versus 60% (group 2) p-value 0.023* ,,Number of dominant follicle ≥17mm significantly more in the same group than in other ( p value 0.00**). Stimulation days are less in group 1 than letrozole only group but no significance. Patients in letrozole cabergoline group had a higher clinical pregnancy rate reaching 27.0% versus 15.0 % in patients of the letrozole group (p- value 0.037*) No difference between both groups in miscarriage ,,multiple gestation , ovarian hyperstimulation rate . Conclusions: higher ovulation & clinical pregnancy rate with the adding cabergoline with letrozole during ovulation induction in euprolactinemic infertile pcos than use letrozole alone. | ||
| Keywords | ||
| Cabergoline Alone or with Letrozol in PCOS | ||
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