Diagnostic Value of Platelets Derived Microparticles in COVID-19 | ||
| Aswan University Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 06 April 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aumj.2025.338121.1160 | ||
| Authors | ||
| Nahla Abdou Hassan* 1; omr AH El Henawy2; Marwa Zanaty Elsayed3; Emad Farah Kholef4; Eslam Fathy Elnakeeb5 | ||
| 1faculty of medicine Aswan university of medicine | ||
| 2Clinical Pathology Department, Faculty of Medicine, Aswan University | ||
| 3Lecture of Internal Medicine, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||
| 4Aswan University hospital | ||
| 5Clinical Pathology department, faculty of medicine, Aswan University | ||
| Abstract | ||
| Abstract Background: Platelet microparticles (PMP) are 0.1-1-micron fragments shed from the plasma membrane of platelets that undergo stress or activation apoptosis. This work aimed to study the PMP's prognostic significance. and their relationship to thrombotic complications in COVID-19 patients. Methods: This prospective case-control work was conducted on 75 COVID-19 patients aged 18 years or more, both sexes, and 25 healthy individuals matched in age and sex. Patients were divided into two groups: Group A (n=75): patients hospitalized with covid 19, and Group B (n=25): The healthy control group. All patients have undergone laboratory investigations [Complete blood count, serum ferritin level, C- reactive protein, D dimer, lactate dehydrogenase, Polymerase Chain Reaction for COVID-19 detection, and ELISA for PMP detection], and radiological assessment [CT chest]. Results: Using the roc curve, it was shown that PMP can be used to discriminate between Group A and Group B at a cutoff level of > 0.65, with 81.3% sensitivity, 76% specificity, 77.2% PPV and 80.3% NPV (AUC = 0.89 & p-value < 0.001). Significant positive association between PMP and age, hospital stay, and D. dimer in group A, and a significant negative correlation between PMP and Hb (P< 0.05). Conclusions: Circulating PMP may serve as a diagnostic biomarker for COVID-19 infections and might be included in the diagnostic method. PMP might work as promising new prognostic indicators for identifying COVID-19 individuals at risk of poor outcomes that require early treatment. Keywords: Platelets; Microparticles; COVID-19; Polymerase Chain Reaction | ||
| Keywords | ||
| Keywords: Platelets; Microparticles; COVID-19; Polymerase Chain Reaction | ||
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