EFFECT OF AMLA (EMBLICA OFFICINALIS) AND CORNSILK (ZEA MAYS L.) AGAINST GENTAMICIN- INDUCED HEPATOTOXICITY AND NEPHROTOXICITY IN EXPERIMENTAL RATS | ||
| Assiut Veterinary Medical Journal | ||
| Article 16, Volume 71, Issue 185, April 2025, Pages 219-239 PDF (1.23 M) | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.2025.343977.1523 | ||
| Authors | ||
| SAFAA T. GOHARI1; EKBAL MAHMOUD MOHAMED2; SHAIMA HEMDAN ABDEL SAMAD3; MARWA S. KHATTAB4; SAMIRA H. ALJUAYDI* 5 | ||
| 11 Nutrition and Food Science, Home Economic Dept., Faculty of Specific Education, Ain Shams Univ., Cairo, Egypt. | ||
| 2Nutrition and Food Science, Home Economic Dept., Faculty of Specific Education, Ain Shams Univ | ||
| 3Nutrition and Food Science, Home Economic Dept., Faculty of Specific Education, Ain Shams Univ., Cairo, Egypt | ||
| 4Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt. | ||
| 5Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt | ||
| Abstract | ||
| Since ancient times, plants have played a vital role in improving mankind and are an excellent source of natural medicines. The difficulty of formulating chemical drugs, their side effects on health, and rising costs have led researchers worldwide to focus on studying medicinal plants. So, the present study aimed to evaluate the effect of amla and cornsilk against gentamicin-induced nephrotoxicity in experimental rats. Thirty male Albino rats were used, and biological, biochemical, oxidative stress and pathological parameters were evaluated. Results showed that the total phenolic values are significantly higher in amla fruit than corn silk, but it is significantly higher in total flavonoid content than amla fruit. Also, they showed excellent antioxidant activity. GM evoked significant alterations in liver and kidney function biomarkers and biological evaluation. Furthermore, elevations in malondialdehyde (MDA) levels and reduction in reduced glutathione (GSH) activity. However, amla fruit and corn silk could mitigate the GM-inflicted liver and kidney damage, this enhancement was also seen in histopathological examination. In conclusion, amla fruit and byproduct cornsilk can be used for the prevention and treatment of hepatotoxicity and nephrotoxicity. | ||
| Keywords | ||
| Amla; Cornsilk; Kidney; Antioxidants | ||
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