Hagag mohamed, A., Eldemerdash, A., hammad, S., Hemaida, T., Alazhary, M. (2025). Age-related differences in functional and post-operative outcomes in spinal anesthesia for open appendectomy with Dexmedetomidine. test, (), -. doi: 10.21608/aumj.2025.372175.1219
Ahmed Mohsen Hagag mohamed; Ayman Mohammady Eldemerdash; soudy salah hammad; Tarek Sayed Hemaida; Mohammed Ahmed Alazhary. "Age-related differences in functional and post-operative outcomes in spinal anesthesia for open appendectomy with Dexmedetomidine". test, , , 2025, -. doi: 10.21608/aumj.2025.372175.1219
Hagag mohamed, A., Eldemerdash, A., hammad, S., Hemaida, T., Alazhary, M. (2025). 'Age-related differences in functional and post-operative outcomes in spinal anesthesia for open appendectomy with Dexmedetomidine', test, (), pp. -. doi: 10.21608/aumj.2025.372175.1219
Hagag mohamed, A., Eldemerdash, A., hammad, S., Hemaida, T., Alazhary, M. Age-related differences in functional and post-operative outcomes in spinal anesthesia for open appendectomy with Dexmedetomidine. test, 2025; (): -. doi: 10.21608/aumj.2025.372175.1219

Age-related differences in functional and post-operative outcomes in spinal anesthesia for open appendectomy with Dexmedetomidine

Aswan University Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 17 April 2025
Document Type: Original Article
DOI: 10.21608/aumj.2025.372175.1219
Authors
Ahmed Mohsen Hagag mohamed* 1; Ayman Mohammady Eldemerdash2; soudy salah hammad3; Tarek Sayed Hemaida3; Mohammed Ahmed Alazhary3
1anesthesia and intensive care at faculty of medicine aswan university ,egypt
2Assistant Professor of Anesthesiology, Surgical Intensive Care and Pain Management, Faculty of Medicine, Aswan University, Aswan, Egypt.
3Lecturer of Anesthesiology, Surgical Intensive Care and Pain Management, Faculty of Medicine, Aswan University, Aswan, Egypt.
Abstract
Abstract

Background: Dexmedetomidine , a selective α2 adrenergic agonist, preserves neurological function and mitigates neuronal damage.

Aim: This study examined age-related variations in the efficacy and postoperative outcomes of DEX in patients undergoing open appendectomy under spinal anesthesia.

Patients and Methods: A prospective observational study was conducted on 74 patients receiving DEX perioperatively. Participants were stratified into four age groups: <20 years (n=12), 20-30 years (n=43), 30-40 years (n=8), and >40 years (n=11).

Results: Intraoperative adverse events (e.g., bradycardia, hypotension) and postoperative outcomes (analgesia duration, VAS scores, Bromage score) showed no significant age-related differences. However, older patients exhibited higher ASA scores (P<0.001), indicating greater comorbidities. VAS scores at 1-hour post-surgery differed significantly (P=0.017), with younger patients reporting lower pain.

Conclusion: While most outcomes were consistent across age groups, the disparity in ASA classification underscores the impact of aging-related comorbidities on perioperative management. The stability of intraoperative and postoperative parameters, including pain and sensory recovery, suggests Dexmeditomidine reliability as a therapeutic agent across diverse ages.

Keywords: Dexmeditomidine, ASA classification, Bromage score.
Keywords
Keywords: Dexmeditomidine; ASA classification; Bromage score
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