Biological effect of Parsley and honey on side effects of Cisplatin induced nephrotoxicity in experimental male rats | ||
| Bulletin of the National Nutrition Institute of the Arab Republic of Egypt | ||
| Article 5, Volume 48, Issue 1, January 2017, Pages 1-23 PDF (1.09 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bnni.2017.4230 | ||
| Author | ||
| Nawal Tahoon | ||
| Department of Home Economic, Faculty of Specific Education, Benha University, Egypt | ||
| Abstract | ||
| The research was carried out on 50 adult albino male rats (Sprague - Dawley strain) weighing 160±7 g. 10 rats served as control negative group and 40 rats were injected with Cisplatin (7.5 mg/kg bwt, ip) to induce nephrotoxicity. Then, rats reclassified into positive control group and three treated rat groups which administered parsley juice with honey, parsley powder with honey, and parsley extract with honey. The treatment period was designed for eight weeks. The chemical composition revealed that dry parsley contain highest amount of protein, fat, ash, calcium, iron, zinc, potassium, sodium, magnesium, total polyphenols and total flavonoids than dry honey but dry honey contain highest amount of carbohydrate and moisture. The biological results revealed that, there was a significant increases in weight gain , food intake , feed efficiency ratio , protein efficiency ratio ,serum total protein , globulin , albumin , and also kidney tissues superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione–S- transferase (GST) antioxidant enzymes. There was a significant decrease in serum creatinine, urea and uric acid and albumin to globulin ratio and kidney tissues malondialdehyde (MDA) in all treated rat groups at p<0.001 compared with positive control group. Rat groups which administered Cisplatin showed a significant increase in creatinine , urea and uric acid and albumin to globulin ratio and kidney tissues malodialdehyde (MDA) and significant decrease in weight gain , food intake , food efficiency ratio , protein efficiency ratio ,serum total protein , globulin, abumin, And kidney tissues superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione –S- transferase (GST) at p<0.001 compared with negative control group and all treated rat groups. Histopathological examination revealed that, kidney tissues of rat treated with administered parsley with honey showed apparent normal kidney and non-histopathological changes. These biochemical changes were accompanied with histopathological. It can be concluded that the administration of Parsley juice, powder and extract with honey can lower the side effects of Cisplatin induced nephrotoxicity in human and reducing the risk factors for nephrotoxicity disease such as hyperemia, leakage of renal markers and healthy condition. | ||
| Keywords | ||
| Parsley; Honey; Nephrotoxicity; Cisplatin & rat | ||
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