Mahmud, G., Zhang, J., Josette, K., Else, J., S., S. (2017). Association between Spot urine Phytoestrogens as Biomarkers on Their Dietary Intake on the Risk of Death from Cancer and Cardiovascular Disease. test, 49(1), 1-35. doi: 10.21608/bnni.2017.4244
Gamil Mahmud; Jones Zhang; Kathryn Josette; Jones Else; Shahat S.. "Association between Spot urine Phytoestrogens as Biomarkers on Their Dietary Intake on the Risk of Death from Cancer and Cardiovascular Disease". test, 49, 1, 2017, 1-35. doi: 10.21608/bnni.2017.4244
Mahmud, G., Zhang, J., Josette, K., Else, J., S., S. (2017). 'Association between Spot urine Phytoestrogens as Biomarkers on Their Dietary Intake on the Risk of Death from Cancer and Cardiovascular Disease', test, 49(1), pp. 1-35. doi: 10.21608/bnni.2017.4244
Mahmud, G., Zhang, J., Josette, K., Else, J., S., S. Association between Spot urine Phytoestrogens as Biomarkers on Their Dietary Intake on the Risk of Death from Cancer and Cardiovascular Disease. test, 2017; 49(1): 1-35. doi: 10.21608/bnni.2017.4244

Association between Spot urine Phytoestrogens as Biomarkers on Their Dietary Intake on the Risk of Death from Cancer and Cardiovascular Disease

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt
Article 4, Volume 49, Issue 1, November 2017, Pages 1-35    PDF (867.48 K)
Document Type: Original Article
DOI: 10.21608/bnni.2017.4244
Authors
Gamil Mahmud1; Jones Zhang1; Kathryn Josette2; Jones Else3; Shahat S.4
1Functional Foods Department, National Institute of Nutrition Canada, Ottawa
2Center for Disease Prevention and Control, Ontario
3National Health and Nutrition Examination Survey (NHANES) Canada
4Food Science and Technology Department, faculty of Agriculture, Al Azhar university, Cairo, Egypt
Abstract
This study suggests that phytoestrogen intake alters cancer and cardiovascular risk. This study investigated the associations of urinary phytoestrogens with total cancer (n = 198), cardiovascular (n = 152), and all-cause (n = 363) mortality among 5179 participants in the continuous National Health and Nutrition Examination Survey Canada (2009–2014). Methods Urinary phytoestrogens were measured using high-performance liquid chromatography with tandem mass spectrometric detection. Survival analysis was per-formed to evaluate hazard ratios (HRs) and 95 % confi-dence intervals (CIs) for each of the three outcomes in relation to urinary phytoestrogens. Results: After adjustment for confounders, higher urinary concentrations of total enterolignans were associated with a reduced risk of death from cardiovascular disease (HR for tertile 3 vs. tertile 10.48; 95 % CI 0.24, 0.97), whereas higher urinary concentrations of total isoflavones (HR for tertile 3 vs. tertile 12.14; 95 % CI 1.03, 4.47) and daidzein (HR for tertile 3 vs. tertile 12.05; 95 % CI 1.02, 4.11) were associated with an increased risk death from Cardiovascular Disease. A reduction in all-cause mortality was observed for elevated urinary concentrations of total enterolignans (HR for tertile 3 vs. tertile 10.65; 95 % CI 0.43, 0.96) and enterolactone (HR for tertile 3 vs. tertile 1 0.65; 95 % CI 0.44, 0.97). Conclusions: Some urinary phytoestrogens were associ-ated with cardiovascular and all-cause mortality in a rep-resentative sample of the Canadian population. This is one of the first studies that used urinary phytoestrogens as biomarkers of their dietary intake to evaluate the effect of these bioac-tive compounds on the risk of death from cancer and car-diovascular disease.
Keywords
Cancer · Cardiovascular disease · Cohort study · Mortality · Urinary phytoestrogens
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