Reda Abd Ellatif, A., El Safy, E., El Masry, N., El-Shabrawy, A. (2020). Neuological Soft signs in euthymic bipolar I patients: State or trait markers.. test, 26(5), 715-724. doi: 10.21608/zumj.2019.13938.1271
Ahmed Rafik Reda Abd Ellatif; Eman Roshdy El Safy; Nagda Mohamed El Masry; Amany El-Shabrawy. "Neuological Soft signs in euthymic bipolar I patients: State or trait markers.". test, 26, 5, 2020, 715-724. doi: 10.21608/zumj.2019.13938.1271
Reda Abd Ellatif, A., El Safy, E., El Masry, N., El-Shabrawy, A. (2020). 'Neuological Soft signs in euthymic bipolar I patients: State or trait markers.', test, 26(5), pp. 715-724. doi: 10.21608/zumj.2019.13938.1271
Reda Abd Ellatif, A., El Safy, E., El Masry, N., El-Shabrawy, A. Neuological Soft signs in euthymic bipolar I patients: State or trait markers.. test, 2020; 26(5): 715-724. doi: 10.21608/zumj.2019.13938.1271

Neuological Soft signs in euthymic bipolar I patients: State or trait markers.

Zagazig University Medical Journal
Article 155, Volume 26, Issue 5, September 2020, Pages 715-724    PDF (650.58 K)
Document Type: Original Article
DOI: 10.21608/zumj.2019.13938.1271
Authors
Ahmed Rafik Reda Abd Ellatif* 1; Eman Roshdy El Safy2; Nagda Mohamed El Masry2; Amany El-Shabrawy3
1Neurosychiatry department at Police Hospitals , Ministry of interior, Egypt.
2Professor of Psychiatry, Faculty of Medicine, Zagazig University, Egypt.
3Assoc. Prof. of Psychiatry, Zagazig University
Abstract
Background: Neurological soft signs (NSS) are endphenotypic markers widely studied in schizophrenia, but few papers have focused on evaluating them in bipolar disorder (BP) and their first degree relatives.
Objectives: the aim of this study was to determine the prevalence and scores of NSS in bipolar I patients in remission state compared to their healthy relatives and controls, in addition to explore correlation with some sociodemographic data and clinical features of these euthymic patients.
Methods: The study was conducted on 30 euthymic bipolar 1 patients, 30 their healthy relatives and 30 control subjects. The neurological soft signs were assessed by the Neurological Evaluation scale (NES). Bipolar I. Euthymic patients were also assessed by young Mania rating scale (YMRS) and the Hamilton Depression rating scale (HDRS). All subjects were recruited from Zagazig university Hospital. A simple questionnaire was structured for all participants to collect some sociodemographic data.
Results: NSS are prevalent in bipolar 1 euthymic patients and their first degree relatives, though significantly more in affected subjects.
Conclusion: This suggests that NSS could be considered as trait marker supporting the theory that bipolar disorder may be a neurodevelopmental disorder.
Keywords
Neurological soft sign; Bipolar Disorder; euthymic patients
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