Acute and late toxicities of adjuvant hypofractionated radiotherapy with weekly concomitant boost for women with early breast cancer | ||
| Sohag Medical Journal | ||
| Article 27, Volume 23, Issue 1, January 2019, Pages 181-186 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/smj.2019.43391 | ||
| Authors | ||
| Mohmed Soliman Gaber1; Ali Mohammed Ali2; Emad El Din Nabil Hassan3; Asmaa Hussein2 | ||
| 1Department of Clinical Oncology , Faculty of Medicine, Sohag University. | ||
| 2Department of Clincal Oncology and Nuclear Medicine, Faculty of Medicine, Sohag University. | ||
| 3Department of Clinical Oncology, Faculty of Medicine, Sohag University. | ||
| Abstract | ||
| The aim of this investigation was to evaluate the feasibility of a shortened whole breast irradiation schedule with a concomitant boost delivered to the tumor bed once a-week in patients with early breast cancer submitted to conservative surgery. Methods: This study included 48 female patients with early breast cancer who underwent breast conservative surgery. There were two arm of radiation, hypofractionated radiotherapy with concomitant boost (group A) - hypofractionated radiotherapy with sequential boost (group B). Results: Acute skin toxicity grade 1 (dry desquamation) was (41.67%) in concomitant boost arm and (25.00%) sequential boost arm. late skin toxicity ,grade 0 was (72.73%) in concomitant boost arm and (54.55%) in sequential boost arm and grade 1 was (9.09%) in concomitant boost arm and (31.82%) in sequential boost arm and grade 2 was (18.19) in concomitant boost arm and (13.55%) in sequential boost arm, grade 3 late lung toxicity was (4.17%) in concomitant boost arm and (12.50%) in sequential boost arm, cardiac toxicity in concomitant boost arm (8.33%) and sequential boost arm (16.67%).The ipsilateral lymphedema after 24 months of follow up G2 (4.55%) in concomitant boost arm G3 (4.55%) in in sequential boost arm. Conclusion: A shortened whole breast irradiation schedule with a weekly concomitant boost may be an alternative option with acceptable toxicity and excellent cosmesis. | ||
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| References | ||
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