Anti Lipase Activity of Rosa damascena Extracts | ||
| Egyptian Journal of Chemistry | ||
| Article 74, Volume 63, Issue 3, March 2020, Pages 861-865 PDF (1.08 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2019.10388.1686 | ||
| Author | ||
| Sahar Alnukari* | ||
| pharmacognosy and medical plants, faculty of pharmacy, Damascus University, Damascus, Syria | ||
| Abstract | ||
| OBESITY is a global health concern associated with high morbidity and mortality.One of the strategies in prevention or treatment of obesity is inhibition of pancreatic lipase responsible of absorption of fats. The aim of this study was to evaluate the anti-lipase activity of Rosa damascena Mill. Petal extracts (hydroalcoholic extract, aqueous extract, essential oil and hydrosol). Extracts were assayed for their in vitro activity against PPL (porcine pancreatic lipase) by using spectrophotometry with 2, 4-dinitrophenyl butyrate as substrate. extracts exhibited different anti-lipase activity, alcoholic extract had the highest (62%) anti-lipase activity and is equivalent to 0.11 μg orlistat/mL. followed by essential oil, aqauose extract and rose water with) 55%, 46 and 20% inhibition), respectively. This study supports investigation of effectiveness of these extracts in vivo to be safe and cheap natural medical replacement in the future. | ||
| Keywords | ||
| Anti lipase activity; Pancreatic lipase; Rosa damascena Mill | ||
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