Reda Abd Ellatif, M., Khashba, A., Sherif, F., Youssef, A., raafat, N. (2021). SERUM BRAIN-DERIVED NEUROTROPHIC FACTOR AMONG MANIC AND EUTHYMIC PATIENTS WITH BIPOLAR DISORDER TYPE I .. test, 27(1), 89-96. doi: 10.21608/zumj.2019.13540.1251
Mohamed Rafik Reda Abd Ellatif; Abd El Shafi Khashba; Fatima Mohamed Sherif; Amira Mohamed Youssef; nermin raafat. "SERUM BRAIN-DERIVED NEUROTROPHIC FACTOR AMONG MANIC AND EUTHYMIC PATIENTS WITH BIPOLAR DISORDER TYPE I .". test, 27, 1, 2021, 89-96. doi: 10.21608/zumj.2019.13540.1251
Reda Abd Ellatif, M., Khashba, A., Sherif, F., Youssef, A., raafat, N. (2021). 'SERUM BRAIN-DERIVED NEUROTROPHIC FACTOR AMONG MANIC AND EUTHYMIC PATIENTS WITH BIPOLAR DISORDER TYPE I .', test, 27(1), pp. 89-96. doi: 10.21608/zumj.2019.13540.1251
Reda Abd Ellatif, M., Khashba, A., Sherif, F., Youssef, A., raafat, N. SERUM BRAIN-DERIVED NEUROTROPHIC FACTOR AMONG MANIC AND EUTHYMIC PATIENTS WITH BIPOLAR DISORDER TYPE I .. test, 2021; 27(1): 89-96. doi: 10.21608/zumj.2019.13540.1251

SERUM BRAIN-DERIVED NEUROTROPHIC FACTOR AMONG MANIC AND EUTHYMIC PATIENTS WITH BIPOLAR DISORDER TYPE I .

Zagazig University Medical Journal
Article 10, Volume 27, Issue 1, January 2021, Pages 89-96    PDF (982.54 K)
Document Type: Original Article
DOI: 10.21608/zumj.2019.13540.1251
Authors
Mohamed Rafik Reda Abd Ellatif* 1; Abd El Shafi Khashba2; Fatima Mohamed Sherif2; Amira Mohamed Youssef3; nermin raafat4
1Psychiatry Department , Zagazig university hospitals, Sharkia governorate, Egypt.
2Professor of Psychiatry, Faculty of Medicine, Zagazig University, Egypt.
3Psychiatry Department , Zagazig university hospitals, Sharkia governorate, Egypt.
4medical biochemistry faculty of medecine zagazig university
Abstract
Background: Bipolar disorders (BD) have been accompanied with disturbances in neuroplasticity. Brain-de‌rived neurotrophic factor (BDNF) plays important role in neuroplasticity. It plays a vital role in the neurobiology of such disorders.
Objectives: This study aimed to check BDNF serum levels in euthymic BD type I patients and correlate them with the clinical manifestations.
Methods: Forty-eight Egyptian individuals were included in this study. They were arranged in three groups: The first one ‘G-A’ included twelve patients diagnosed with bipolar I disorder in manic episode; while the second ‘G-B’ consisted of twelve patients diagnosed with bipolar I disorder in full remission, and the third group ‘G-C’ consisted of 24 healthy persons as control subjects. The cases were diagnosed according to DSM-5 and psychometric analysis. The BDNF levels were assessed using the technique of quantitative sandwich enzyme immunoassay.
Results: There was no statistical significant difference between the studied groups as regard demographic characteristics. Serum BDNF levels were lower in bipolar I patients in manic episode compared with those in euthymic state and also control subjects.
Conclusion: patients with manic episode of bipolar I disorder have lower serum BDNF levels compared with those with euthymic state and control group.
Keywords
Brain-derived neurotrophic factor; Bipolar Disorder; manic episode; euthymia
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