Abdelghani, A., Atwa, Y., Mansy, W., Morsi, M. (2020). Current Modalities in Management of Early-stage Hepatocellular Carcinoma. test, 26(6), 908-918. doi: 10.21608/zumj.2019.13881.1269
Amr Abdelghani; Yehia Atwa; Wael Salah Eldin Mansy; Mors Mohamed Morsi. "Current Modalities in Management of Early-stage Hepatocellular Carcinoma". test, 26, 6, 2020, 908-918. doi: 10.21608/zumj.2019.13881.1269
Abdelghani, A., Atwa, Y., Mansy, W., Morsi, M. (2020). 'Current Modalities in Management of Early-stage Hepatocellular Carcinoma', test, 26(6), pp. 908-918. doi: 10.21608/zumj.2019.13881.1269
Abdelghani, A., Atwa, Y., Mansy, W., Morsi, M. Current Modalities in Management of Early-stage Hepatocellular Carcinoma. test, 2020; 26(6): 908-918. doi: 10.21608/zumj.2019.13881.1269

Current Modalities in Management of Early-stage Hepatocellular Carcinoma

Zagazig University Medical Journal
Article 3, Volume 26, Issue 6, November 2020, Pages 908-918    PDF (790.67 K)
Document Type: Original Article
DOI: 10.21608/zumj.2019.13881.1269
Authors
Amr Abdelghani* 1; Yehia Atwa1; Wael Salah Eldin Mansy1; Mors Mohamed Morsi2
1Department of General Surgery- Faculty of Medicine- Zagazig University- Egypt
2Department of General Surgery - Faculty of Medicine- Zagazig University
Abstract
BACKGROUND & AIM:
Multiple discussions have been aroused regarding which approach is the most suitable for treating early-stage HCCs: Surgical resection, radiofrequency ablation (RFA) or microwave ablation (MWA).
The purpose of this study was to test the null hypothesis: "The effect of LR, RFA and MWA do not differ from each other as current modalities for early hepatocellular carcinoma < 5cm".
METHODS:
This prospective study enrolled 45 patients diagnosed with early HCC. Patients had the criteria of: (Solitary lesions, tumor size < 5 cm, Class of Child-Pugh: A/ B only). Patients were sub-divided into equally three groups: (15) patients underwent liver resection. (15) patients subjected to RFA , and (15) patients treated with MWA from April 2016, to March 2019.
Results:
Our results showed that three modalities(LR, RFA and MWA) did not differ significantly regarding the overall survival (OS) rates for tumors< 5cm(P= 0.3). However, significant difference was found between the three groups (LR, RFA and MWA) regarding rate of overall complications (P= 0.001). Regarding rate of minor complications, there was a significant difference between LR, RFA and MWA by (26.67%., 93.3%, 86.7%) respectively with (P= 0.001). Rate of major complications differed significantly between the three groups (P=0.01) as follows: (LR, RFA and MWA) by (26%, 0 % and 0 %) respectively.
Conclusion:
RFA and MWA are equal to be an effective alternative to liver resection (LR) patients as a primary therapy for early-stage HCCs measuring as large as
Keywords
Early hepatocellular carcinoma; surgical resection; microwave; Radiofrequency
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