In Vitro Study of Anticancer Effect of N Acetyl Cysteine –Metal Complexes as New Target Drugs on Human Cancer Cell Lines | ||
| Benha Veterinary Medical Journal | ||
| Article 17, Volume 34, Issue 3, August 2018, Pages 206-217 PDF (781.48 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bvmj.2018.44746 | ||
| Authors | ||
| Omayma A. R. AbouZaid1; Eman Noaman2; Shaimaa abdelAti3; Gehad Genidy Mohamed4 | ||
| 1Biochemistry Department, Faculty of Vet. Med. Moshtohor, Benha University, Egypt | ||
| 2Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Egypt. | ||
| 3Inorganic Chemistry Dept., Faculty of Science, Cairo University. | ||
| 4Post graduate student | ||
| Abstract | ||
| One of the main methods of modern cancer treatment is drug therapy but, it is found to be difficult to cure effectively. N-acetylcysteine (NAC), which is a membrane-permeable metal-binding compound, might have anti-cancer activity in the presence of different metals. In the present study synthesis of NAC with (Cu, Zn, Cd, Fe, Mg, Mn, Cr, Ni, Co, Se and Ag) by metals investigation and the formation of these complexes by IR, NMR. The effect of cytotoxicity of these complexes on Breast, Liver, Prostate and Ovary human cancer cell lines were evaluated. The best complexes were seen in cadmium N acetyl cysteine complex in breast, ovary, prostate and liver cell line. | ||
| Keywords | ||
| N acetyl cysteine; Metal complexes; IR; NMR; human cancer cell line | ||
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