Programmed Necrosis-mediated Cell Death and Disease: Recent Advances | ||
| Suez Canal University Medical Journal | ||
| Editorial, Volume 17, Issue 1, March 2014, Pages 1-9 PDF (187.36 K) | ||
| DOI: 10.21608/scumj.2014.45311 | ||
| Author | ||
| Maged M Harraz* | ||
| Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, USA | ||
| Abstract | ||
| Cell death classification has been based on morphological characteristics for decades. Modern advances in molecular technology enabled us to explore cell death pathways on a level of unprecedented detail. While necrosis has been considered a negative unpreventable form of cell death, recent findings demonstrate that a subtype of necrosis, namely necroptosis, is a regulated programmed process. Hence, therapeutic intervention to inhibit necroptosis-mediated loss of cells in a disease process is possible. This review highlights recent advances in programmed necrosis (necroptosis) and its potential relationship to human disease. | ||
| Keywords | ||
| Necroptosis; programmed cell death; necrosis; caspase-independent cell death | ||
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