MicroRNA Applications in Human Cancers | ||
| Suez Canal University Medical Journal | ||
| Editorial, Volume 17, Issue 2, October 2014, Pages 75-85 PDF (254.09 K) | ||
| DOI: 10.21608/scumj.2014.46458 | ||
| Authors | ||
| Ola Leheta* 1, 2; Gehan Ibrahim3, 4 | ||
| 1Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Egypt | ||
| 2Academic Quality Unit, College of Medicine, King Saud University, KSA | ||
| 3Medical Biochemistry Department, Faculty of Medicine, Suez Canal University, Egypt | ||
| 4Basic Sciences Department, College of Medicine, Princess Nora University, KSA | ||
| Abstract | ||
| Over the last decade, a family of noncoding RNA molecules, including microRNA (miRNA) has been discovered. MiRNAs have been implicated as key regulators of different cellular processes many of which are associated with cancer. They contribute to the pathogenesis of human cancers; in addition, they may function as oncogenes or tumor suppressors in tumor development. The unique expression profile of microRNAs in different types and subsets of tumor, besides to their possible identification in biological fluids indicate that they might serve as molecular biomarkers for cancer diagnosis, prognosis, and prediction of therapeutic responses. However, they should achieve remarkable sensitivity and specificity, reproducibility and consistency between different studies. Accumulating evidence suggests that alterations of miRNAs expression may ultimately yield new therapeutic strategies against cancer or at least guide clinical decision making. The current review will give an overview on miRNAs, with a focus on their applications in human cancer diagnosis, prognosis, and therapy. | ||
| Keywords | ||
| cancer therapy; microRNA; tumorogenesis | ||
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