FORMULATION,CHARACTERIZATION AND IN-VITRO RELEASE OF ORAL FELODIPINE SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS | ||
| Al-Azhar Journal of Pharmaceutical Sciences | ||
| Article 2, Volume 57, Issue 1, March and April 2018, Pages 18-51 PDF (1.46 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajps.2018.46619 | ||
| Author | ||
| amr Shaaban | ||
| Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt | ||
| Abstract | ||
| Nanotechnology is a cross-disciplinary field, which involves the ability to design and exploit the unique properties that emerge from man-made materials ranging in size from 1 to greater than 100 nm.A self- nanoemulsifying drug delivery system is a fairly similar liquid lipid dosage form designed for oral delivery which composed of oils, surfactants and possibly cosurfactants or cosolvents.Felodipine is a calcium channel blocker (CCB). It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. The aim of this paper was to formulate Felodipine self nanoemulsifying system to overcome the poor aqueous solubility of Felodipine (3ug/ml) and hence improving its poor dissolution which is the main cause of its poor oral bioavailability. Evaluation, Characterization and In-Vitro release of orally Felodipine Self-nanoemulsifying Drug Delivery Systems were studied in comparison with the market product. Formulae B18 (composed of 30% Triacetin: 40% Span 80: 30% Transcutol HP) and C19 (composed of 20% Triacetin: 50% Span 80: 30% Ethanol) were selected for Felodipine SNEDDS.Felodipine SNEDDSs prepared using Transcutol HP (B18) exhibited pseudoplastic flow while Felodipine SNEDDSs prepared using ethanol (C19) exhibited Newtonian flow.Formula prepared with Transcutol HP (B18) has smaller droplet size and PDI than that prepared with ethanol (C19). Felodipine formulae showed negative zeta potential values.The in-vitro release can be arranged in descending order as follows: Felodipine formula B 18 > Felodipine formula C 19 > Market product. | ||
| Keywords | ||
| Felodipine; In-vitro; Self-nanoemulsifying Drug Delivery Systems; Solubility; oral bioavailability | ||
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