Farahat, A., Ismael, M., Mahmoud, S., Ghanem, A. (2018). Evaluation of Reactivation of Inhibited Acetyl Cholinesterase Enzyme in Patients Intoxicated With Organophosphorus Insecticide. test, 26(1), 65-76. doi: 10.21608/mjfmct.2018.46732
Alsayed Farahat; Magdy A Ismael; Sherif F Mahmoud; Abdel Aziz A Ghanem. "Evaluation of Reactivation of Inhibited Acetyl Cholinesterase Enzyme in Patients Intoxicated With Organophosphorus Insecticide". test, 26, 1, 2018, 65-76. doi: 10.21608/mjfmct.2018.46732
Farahat, A., Ismael, M., Mahmoud, S., Ghanem, A. (2018). 'Evaluation of Reactivation of Inhibited Acetyl Cholinesterase Enzyme in Patients Intoxicated With Organophosphorus Insecticide', test, 26(1), pp. 65-76. doi: 10.21608/mjfmct.2018.46732
Farahat, A., Ismael, M., Mahmoud, S., Ghanem, A. Evaluation of Reactivation of Inhibited Acetyl Cholinesterase Enzyme in Patients Intoxicated With Organophosphorus Insecticide. test, 2018; 26(1): 65-76. doi: 10.21608/mjfmct.2018.46732

Evaluation of Reactivation of Inhibited Acetyl Cholinesterase Enzyme in Patients Intoxicated With Organophosphorus Insecticide

Mansoura Journal of Forensic Medicine and Clinical Toxicology
Article 6, Volume 26, Issue 1, January 2018, Pages 65-76    PDF (419.88 K)
Document Type: Original Article
DOI: 10.21608/mjfmct.2018.46732
Authors
Alsayed Farahat* 1; Magdy A Ismael2; Sherif F Mahmoud2; Abdel Aziz A Ghanem3
1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Al-Azher University (Assiut)
2Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Al-Azher University.
3Forensic Med. & Clin. Toxicology, Mansoura Faculty of Medicine
Abstract
Pesticides are a large and heterogeneous group of chemicals which have long been used to control and repel pests in different fields.The organophosphates are the most widely used pesticides in industry, agriculture and houses. This study intends to evaluate the effectiveness of obidoxime therapy for reactivation of cholinesterase enzyme and its correlation with severity of poisoning among organophosphorus poisoning cases presented to Mansoura poisoning control unit (received oxime as aline of therapy) and Damietta general hospital, (did not received oxime as aline of therapy) during the period from 1st March 2015 to the end of February 2017. A total number of 303 patients presented with acute anticholiesterase poisoning (150 in Damietta and 153 in Mansoura Emergency Hospital). A total of 250 cases were diagnosed to be organophosphorus by TLC {112 in Damietta and 138 in Mansoura emergency hospital} and only 200 of them were included in this study according to exclusion criteria. Data on evaluation of obidoximes in treatment of organophosphorus (OP) poisoning incorporating the maximal clinical parameters and comparing the two groups in an unbiased manner, revealed that the use of obidoximes decreased the required dose of atropine and duration of hospital stay when compared with atropine alone. It is clear that there may be potential benefit from oximes as acetyl cholinesterase (AChE) activity is clearly increased by treatment.
Keywords
Organophosphorus; Oxime; Mansoura; Damietta
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