Activation Role of Low Dose Ionizing Radiation on Human Lymphocytes Response | ||
| Egyptian Journal of Radiation Sciences and Applications | ||
| Article 1, Volume 31, Issue 2, December 2018, Pages 89-95 PDF (515.24 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejrsa.2017.1816.1022 | ||
| Authors | ||
| Sherien Montaser* ; Gehan Roshdy Abdel Hamid; Ahmad Rashad Aboghadeer | ||
| Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, P. O. Box: 29 Nasr City, Egypt | ||
| Abstract | ||
| LOW dose ionizing radiation can imitate the role of deteriorate antigen or attenuated microbes as it activates the first defence line of immune response, the step which when lost, cancer cells can find suitable environmental condition for growth propagation. Human whole blood samples were irradiated in vitro at doses (0.25, 0.5, 0.75 and 1Gy) of ionizing radiation and then kept at 37oC for 1h before measuring glucose concentrations which reflect the maximum activation of immune cells. Then, immunological parameters such as interlukine-1β (IL-1β), interlukine-2 (IL-2), transforming growth factor beta (1) (TGF-β1) were investigated. Also, inflammatory mediators as intracellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and tyrosine kinase activity were determined. Low doses of ionizing radiation induced slight activation of the immune cell cytokines (IL-1β and TGF-β1), inflammatory mediators (ICAM, VCAM) and tyrosine kinase activity at doses (0.25, 0.5Gy) reaching to significant levels at 0.75Gy and 1Gy. While, IL-2 and glucose levels were significantly decrease. | ||
| Keywords | ||
| Gmama-irradiation; IL-1β; IL-2; TGF-β; ICAM and VCAM | ||
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