Beneficial Effects of Piperine in global cerebral ischemia/reperfusion model in irradiated rats | ||
| Egyptian Journal of Radiation Sciences and Applications | ||
| Article 6, Volume 30, Issue 2, December 2017, Pages 161-170 PDF (1.13 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejrsa.2017.2052.1026 | ||
| Authors | ||
| Samar Azab1; Walaa Adel Elsabbagh2; Mohammed M. Abd El-Daim3; Engy Rashed* 4 | ||
| 1Faculty of Pharmacy - Ain Shams University | ||
| 2Drug Radiation Research Department, NCRRT | ||
| 3Faculty of Veterinary Medicine, Suez Canal University | ||
| 4National Center for Radiation Research and Technology | ||
| Abstract | ||
| Stroke is the third cause of death and a leading cause of chronic disability all around the world. Inflammation and oxidative stress are common pathogenic pathways of brain injury induced by ischemia/reperfusion (I/R). This work aims to investigate the possible role of Piperine as antioxidant and anti-inflammatory in attenuating the cerebral ischemia/reperfusion (I/R)-induced brain injury in whole body γ-irradiated rats. Global cerebral ischemia was induced in both irradiated and non-irradiated male Wistar rats, and was followed by reperfusion. The beneficial effect of pretreatment with piperine (10 mg/kg, once daily p.o. for 15 days) was examined on cerebral ischemia-induced brain injury in 24 h pre-irradiated (6 Gy) male Wistar rats. I/R increased brain content of malondialdehyde (MDA) and decreased its glutathione (GSH) content and total antioxidant capacity (TAC). It also raised serum lactate dehydrogenase (LDH) activity and brain cytosolic calcium (Ca2+) level. Pre-treatment with piperine significantly attenuated brain injury in I/R irradiated rats by decreasing cytosolic brain calcium level and serum lactate dehydrogenase (LDH) activity. In addition, a significant decrease in nuclear factor kappa-B (NF-kB) was recorded in piperine treated group. These findings indicate that administration of piperine ameliorated most of the tested biochemical changes induced by I/R in irradiated rat brain and serum. | ||
| Keywords | ||
| Cerebral ischemia/reperfusion; gamma radiation; Piperine; Inflammation; Oxidative Stress | ||
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