Fikry, R., Zein, N., Faozan, A. (2018). Properties of Crocus sativus Saffron on DEN-induced Hepatocellular Carcinoma in Rats. test, 14(1), 171-179. doi: 10.21608/blj.2018.47618
Reda Fikry; Nabila Zein; Asmaa Faozan. "Properties of Crocus sativus Saffron on DEN-induced Hepatocellular Carcinoma in Rats". test, 14, 1, 2018, 171-179. doi: 10.21608/blj.2018.47618
Fikry, R., Zein, N., Faozan, A. (2018). 'Properties of Crocus sativus Saffron on DEN-induced Hepatocellular Carcinoma in Rats', test, 14(1), pp. 171-179. doi: 10.21608/blj.2018.47618
Fikry, R., Zein, N., Faozan, A. Properties of Crocus sativus Saffron on DEN-induced Hepatocellular Carcinoma in Rats. test, 2018; 14(1): 171-179. doi: 10.21608/blj.2018.47618

Properties of Crocus sativus Saffron on DEN-induced Hepatocellular Carcinoma in Rats

Biochemistry Letters
Article 14, Volume 14, Issue 1, 2018, Pages 171-179    PDF (516.84 K)
Document Type: Original Article
DOI: 10.21608/blj.2018.47618
Authors
Reda Fikry; Nabila Zein; Asmaa Faozan
Chemistry Department-Faculty of Science, Zagazig university, Egypt
Abstract
The purpose of this study was to investigate the possible mechanisms of Crocus sativus saffron against diethylnitrosamine (DEN)-induced liver cancer in rats. Administration of Crocus sativus saffron at a dose of 300 mg/kg/day was started 2 weeks prior to the DEN and CCL4 injection and was continued for 42 days. Crocus sativus saffron significantly reduced the DEN-induced increase in the number and the incidence of hepatic dyschromatic nodules, saffron restored the superoxide dismutase, catalase and malondialdehyde levels and increased the expression of active caspase 3 and inhibited the formation of MMP9 
Keywords
Saffron; DEN; CCl4; HCC; caspase and MMP
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