Ahmad, N., Abdelmoaty, M., Saleem, T., Galal, G., Morad, A. (2019). RESEARCH ARTICLE SERUM SYNDECAN-1 AND APOLIPOPROTEIN A1 IN PATIENTS WITH CHRONIC HCV INFECTION. test, 23(2), 204-218. doi: 10.21608/smj.2019.47719
Nagwa Sayed Ahmad; Mohamed Ahmed Abdelmoaty; Tahia H Saleem; Ghada Moustafa Galal; Amira Morad. "RESEARCH ARTICLE SERUM SYNDECAN-1 AND APOLIPOPROTEIN A1 IN PATIENTS WITH CHRONIC HCV INFECTION". test, 23, 2, 2019, 204-218. doi: 10.21608/smj.2019.47719
Ahmad, N., Abdelmoaty, M., Saleem, T., Galal, G., Morad, A. (2019). 'RESEARCH ARTICLE SERUM SYNDECAN-1 AND APOLIPOPROTEIN A1 IN PATIENTS WITH CHRONIC HCV INFECTION', test, 23(2), pp. 204-218. doi: 10.21608/smj.2019.47719
Ahmad, N., Abdelmoaty, M., Saleem, T., Galal, G., Morad, A. RESEARCH ARTICLE SERUM SYNDECAN-1 AND APOLIPOPROTEIN A1 IN PATIENTS WITH CHRONIC HCV INFECTION. test, 2019; 23(2): 204-218. doi: 10.21608/smj.2019.47719

RESEARCH ARTICLE SERUM SYNDECAN-1 AND APOLIPOPROTEIN A1 IN PATIENTS WITH CHRONIC HCV INFECTION

Sohag Medical Journal
Article 38, Volume 23, Issue 2, April 2019, Pages 204-218    PDF (121.45 K)
Document Type: Original Article
DOI: 10.21608/smj.2019.47719
Authors
Nagwa Sayed Ahmad1; Mohamed Ahmed Abdelmoaty2; Tahia H Saleem3; Ghada Moustafa Galal4; Amira Morad2
1Debartment of Biochemistry, Faculty of Medicine, Sohag University.
2Departments of Medical Biochemistry, Faculty of Medicine, Sohag University.
3Departments of Medical Biochemistry, Faculty of Medicine, Assuit University.
4Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Sohag University.
Abstract
Hepatitis C virus (HCV) is endemic in Egypt. Over 15% of populations of the people in Egypt are infected, this is ten times greater than in any other country in the world. To validate a simple, inexpensive, non invasive markers (Fib-4, APRI, syndecan-1 and apolipoprotein A-1(ApoA-1) for detection of liver fibrosis in patients with chronic HCV and thereby reduce the need for liver biopsy. Estimation of serum syndecan-1 and apoA-1 by ELISA were done on 20 normal healthy persons and 57 chronic hepatitis C patients, the patients were staged according to liver biopsies (Metavir fibrosis staging) (stage f1=15, f2=15, f3=14,f4= 13). The area under the receiver operating characteristic (ROC) curve (AUC) of syndecan-1=(0.72), the mean level of plasma syndecan-1 was significantly higher in chronic HCV patients when compared to control subjects (P=0.0008), but the mean level of ApoA-1 was not significantly different from that of controls (p=o.65), and it had significant negative correlation to the stage of fibrosis (AUC=0.57). Moreover the APRI and Fib-4 were proved significantly directly correlated with fibrosis stage of the studied patients. This study not reveals putative biomarkers of liver fibrosis (syndecan-1, ApoA-1 APRI, Fib-4) but also proves the differential expression of those markers in different stages of fibrosis. It is expected that combination of these novel biomarkers could be applied clinically to predict the stage of liver fibrosis without the need of liver biopsy.

 
Copyright © 2015 Nagwa S. Ahmed et al. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords
Syndecan-1; ApoA-1; Chronic hepatitis C; non-invasive marker; Liver Biopsy
Supplementary Files
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