Control of Hyperlipidemia in Rats By Using Papaya and Stirred Yoghurt | ||
| Egyptian Journal of Nutrition and Health | ||
| Article 6, Volume 9, Issue 1, January 2014, Pages 1-24 PDF (4.23 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejnh.2014.4818 | ||
| Authors | ||
| Nagib M; El- Kewawy E | ||
| Home Economics Dept., Faculty of Specific Education, Mansoura University, Mansoura, Egypt | ||
| Abstract | ||
| Current research aims to study the effect of feeding on stirred yoghurt only, papaya only and stirred yoghurt supplemented with 20% papaya on hyperlipidemia male rats. The study was conducted on 36 male albino rats divided into two main groups, the first main group 6 rats were fed on basal diet only and contrived as control group, while the second main group 30 rats with induced hypercholesterolemia through nutrition on a diet high in cholesterol content1%, the second group were divided into five equal subgroups and fed for 2 months.one subgroup was left as a positive control group (Group 1),whereas group (2)was treated with atorvastatin (10 mg/kg) orally, while groups(3,4,5) have been fed adding stirred yoghurt only , papaya only and stirred yoghurt supplemented with 20% papaya by rate (5m1/kg b.w) orally using a stomach tube daily for 8 weeks. The results revealed that all treated rat groups(experimental groups) showed a significant decrease in TC , TG , LDL-C ,VLDL-C homocysteine, TC / HDL-C and LDL-C / HDL-C than positive control group , while HDL-c was increased , in compared with the control (+ve) group. As a result, the best values of these variables appeared in stirred yoghurt supplemented with 20% papaya , atorvastatin and papaya only in compared with the other treated groups .The results revealed that liver enzymes (AST, ALT) showed significant decrease in all treated rat groups , All treated groups showed a significant increase in SOD, GSH and CAT and showed a significant decrease in MDA compared with the control (+ve) group. Histopathological examination of the rat's hearts confirmed this amelioration in rats group that consumed stirred yoghurt supplemented with 20% papaya . The study recommended the use of stirred yoghurt supplemented with 20% papaya in patients meals suffering from hyperlipidemia. | ||
| Keywords | ||
| Stirred Yoghurt; Papaya; hyperlipidemia; Cholesterol; triglyceride; liver functions- antioxidant enzymes | ||
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