METFORMIN TREATMENT IN INSULIN RESISTANT POLYCYSTIC OVARIES PATIENTS | ||
| The Egyptian Journal of Fertility and Sterility | ||
| Article 4, Volume 9, 1,2, January 2005, Pages 29-36 PDF (513.05 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/egyfs.2005.5001 | ||
| Authors | ||
| Seham El Berry; Ahmed Mansour | ||
| Department of Obstetrics & Gynecology, Benha Faculty of Medicine | ||
| Abstract | ||
| Objectives: To know the incidence and characters of insulin resistance (lR) in polycystic ovaries (PCO) patients, and the efficacy of metformin treatment for induction of ovulation compared to clomiphene citrate (CC); also the effect of .metformin on the clinical, biochemical and hormonal features of the patient would be evaluated. Design: A prospective, blind, controlled study. Setting: Outpatient infertility clinic, Benha University Hospital. Subjects: Sixty infertile PCO patients. Methods: The body mass index (BMI), the hirsutism and the acne scores, the fasting blood glucose, the fasting serum insulin and serum testosterone levels were measured for every patient. A ratio of fasting blood glucose to fasting serum insulin (G/I) of less than 4.5 mgllO-4 untis was considered IR. Insulin resistant patients were randomly divided into three groups and treated for three cycles. The first group was treated with CC + mctforrnin, the second with placebo + metformin and the third with CC + placebo. Main outcome measures: The ovulation and pregnancy rates with metformin treatment compared to CC. Results: IR is present in about 86.6% of PCO patients. They are characterized by having higher BML fasting serum insulin and serum testosterone levIes, than non IR patients. Treatment with CC + mctformin results in higher ovulation and pregnancy rates compared to that obtained with CC alone. Conclusions: IR must be diagnosed in PCO patients. Induction of ovulation with CC + mctforrnin results in higher ovulation and pregnancy rates. In contrast to ce, the longer the duration of metformin treatment, the better arc the results. | ||
| Keywords | ||
| missed | ||
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