Synthesis and Study Antimicrobial Activities of Some Novel Tetrazole Derivatives | ||
| Egyptian Journal of Chemistry | ||
| Article 18, Volume 61, Issue 1, January and February 2018, Pages 197-206 PDF (1.58 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2018.2214.1178 | ||
| Authors | ||
| Maher Nessim* 1; Safaa I. Elewa2; Manal G. Mohamed1 | ||
| 1Egyptian Petroleum Research Institute | ||
| 2Faculty of women for arts, science and education, Ain Shams University | ||
| Abstract | ||
| Four (2-phenol derivatives) were coupled with 1H-tetrazole-5-diazonium chloride to synthesize four new compounds namely Ta-d. These prepared Azophenols reacted with two 4-alkoxy acids (8 and 10) to form two new series of 4-((1H-tetrazol-5-yl) diazenyl)-2-(R)-phenyl-4-(octyloxy) benzoates T8a-d and 4-((1H-tetrazol-5-yl)diazenyl)-2-(R)-phenyl-4-(decyloxy) benzoates T10a-d respectively. The structures of the twelve synthesized compounds were confirmed using the conventional tools of analysis, Elemental Analysis, FT-IR and 1H-NMR spectroscopy. They were tested as anti-fungi and anti-bacteria. Most of the prepared compounds possessed good antimicrobial action for Gram Positive and Gram-Negative Bacteria, whereas they gave no action on Aspergillus Fumigatus or Candida albicans. | ||
| Keywords | ||
| Tetrazoles; Diazotization; phenols; 1H-NMR; Biological Activity | ||
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