Evaluation of osteopathy and vitamin D status in patients with beta-thalassemia major | ||
| Zagazig University Medical Journal | ||
| Article 244, Volume 27, Issue 5, September 2021, Pages 776-781 PDF (352.56 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2019.10819.1127 | ||
| Authors | ||
| mohamed ragab qwader* 1; laila mitwaly sherief2; Adel Ahmed Sherif3; Ahmed Mohamed Baraka4 | ||
| 1Department of pediatrics, faculty of medicine, Zawia university , Zawia ,Libya | ||
| 2Department of pediatric ,Faculty of medicine ,Zagazig university | ||
| 3Department of Pediatrics Faculty of Medicine - Zagazig University | ||
| 4Department of clinical pathology , faculty of medicine , Zagazig University | ||
| Abstract | ||
| Background: The survival of patients with thalassemia major has progressively improved with advances in therapy; however, osteoporosis and cardiac dysfunction remain frequent complications. Adequate circulating levels of vitamin D are essential for optimal skeletal health and reducing fracture risk this study aimed to evaluate the density of bone mineral (BMD) and vitamin D status in patients with β-thalassemia major (β-TM). Methods: The current study was carried on thirty three β-thalassemic childrens who attend the Pediatric Hematology Clinic at Zagazig University Hospitals during the period from April 2018 to October 2018 (21 male and 12 female). Dual-energy X-ray absorptiometry scan was used to evaluate bone density and interpreted as Z-score which compared to the BMD of age, sex and ethnicity-matched reference population. Biochemical parameters such as calcium, serum ferritin (SF) and 25-OH Vitamin D have been evaluated. Results: there were significant increase in serum ferritine level, AST, ALT, ALP, total bilirubin and urea and decrease in total protien , serum albumin and criatinine in the thalassaemic patients than controls. There was significant low level of vitamin k2 in the thalassaemic patients than controls Conclusion: Osteopathy has a high prevalence in patients with β-TM and should receive an optimal transfusion and chelation therapy to prevent bone expansion. Calcium and Vitamin D should be routinely determined to prevent deficiency. | ||
| Keywords | ||
| Beta-thalassemia major; Osteoporosis; Osteopenia; 25 (OH) cholecalciferol | ||
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