Marei, A., Boghdadi, G., Tash, R., Elgharabawy, E. (2020). Efficacy of intralesional Candida antigen immunotherapy in treatment of recalcitrant warts.. test, 26(5), 769-774. doi: 10.21608/zumj.2019.16153.1443
Ayman Marei; Ghada Boghdadi; Rehab M.Elsaid Tash; Eman Elgharabawy. "Efficacy of intralesional Candida antigen immunotherapy in treatment of recalcitrant warts.". test, 26, 5, 2020, 769-774. doi: 10.21608/zumj.2019.16153.1443
Marei, A., Boghdadi, G., Tash, R., Elgharabawy, E. (2020). 'Efficacy of intralesional Candida antigen immunotherapy in treatment of recalcitrant warts.', test, 26(5), pp. 769-774. doi: 10.21608/zumj.2019.16153.1443
Marei, A., Boghdadi, G., Tash, R., Elgharabawy, E. Efficacy of intralesional Candida antigen immunotherapy in treatment of recalcitrant warts.. test, 2020; 26(5): 769-774. doi: 10.21608/zumj.2019.16153.1443

Efficacy of intralesional Candida antigen immunotherapy in treatment of recalcitrant warts.

Zagazig University Medical Journal
Article 246, Volume 26, Issue 5, September 2020, Pages 769-774    PDF (519.9 K)
Document Type: Original Article
DOI: 10.21608/zumj.2019.16153.1443
Authors
Ayman Marei1; Ghada Boghdadi2; Rehab M.Elsaid Tash3; Eman Elgharabawy* 4
1Microbiology and Immunology Dept., Faculty of medicine, Zagazigig University
2Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University,
3Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University
4Medical Microbiology and Immunology, Faculty of Medicine,Zagazig university
Abstract
Background Despite existence of different therapeutic modalities, treatment of warts especially recalcitrant one remains a continuing challenge as there is no treatment modality exhibited high efficiency and low recurrence rate. Recently, intralesional immunotherapy via different types of antigens has proved high efficacy in the treatment of different types of warts.
Objective To evaluate the efficacy and safety of intralesional Candida antigen in treatment of recalcitrant warts.
Methods The study included 24 patients with recalcitrant warts. All patients were injected with 0.2 ml of 1/1000 solution of C. albicans antigen at 2-week intervals until complete clearance or for a maximum of six treatment sessions. Follow-up was done every month for six months to detect any recurrence.
Results 14 patients (58.3%) showed complete response, 6 patients (25%) showed partial response and 4 patients (16.7%) showed no response with no change in warts size throughout treatment sessions. Adverse effects were insignificant and no recurrence of warts was detected.
Conclusion Intralesional Candida antigen immunotherapy is a safe, promising and effective treatment modality for recalcitrant warts.
Keywords
Candida antigen; Immunotherapy; recalcitrant warts
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