sabry, H., Hamed, A., Sabry, J., Abdel-Salama, O. (2017). YKL-40: An Emerging Biomarker of Endothelial Dysfunction in Arteriogenic Erectile Dysfunction. test, 7(3), 98-104. doi: 10.21608/ha.2017.904.1001
hanan hassan sabry; Ahmed H. Hamed; Jehan H. Sabry; Osama H. Abdel-Salama. "YKL-40: An Emerging Biomarker of Endothelial Dysfunction in Arteriogenic Erectile Dysfunction". test, 7, 3, 2017, 98-104. doi: 10.21608/ha.2017.904.1001
sabry, H., Hamed, A., Sabry, J., Abdel-Salama, O. (2017). 'YKL-40: An Emerging Biomarker of Endothelial Dysfunction in Arteriogenic Erectile Dysfunction', test, 7(3), pp. 98-104. doi: 10.21608/ha.2017.904.1001
sabry, H., Hamed, A., Sabry, J., Abdel-Salama, O. YKL-40: An Emerging Biomarker of Endothelial Dysfunction in Arteriogenic Erectile Dysfunction. test, 2017; 7(3): 98-104. doi: 10.21608/ha.2017.904.1001

YKL-40: An Emerging Biomarker of Endothelial Dysfunction in Arteriogenic Erectile Dysfunction

Human Andrology
Article 3, Volume 7, Issue 3, September 2017, Pages 98-104    PDF (556.35 K)
Document Type: Original Article
DOI: 10.21608/ha.2017.904.1001
Authors
hanan hassan sabry* 1; Ahmed H. Hamed2; Jehan H. Sabry3; Osama H. Abdel-Salama2
1Dermatology, Venereology and Andrology, Benha Faculty of medicine , Benha University,Egypt
2Departments of Dermatology Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt
3Clinical and chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt
Abstract
Introduction: Endothelial dysfunction is a central etiologic factor in the development of atherosclerosis and systemic vascular disease, which includes erectile dysfunction.  YKL-40 has been suggested to be a new marker of inflammation, atherosclerosis, and endothelial dysfunction.  Aim: To estimate serum levels of YKL40, as a new serum marker of endothelial dysfunction, in patients with arteriogenic erectile dysfunction.  Patients and Methods: Hundred subjects including 50 with arteriogenic erectile dysfunction and 50 healthy as a control group were enrolled to the study. Serum YKL-40 levels were measured in patients and controls using ELISA technique.  Results: Serum YKL-40 levels was significantly elevated in arteriogenic ED patients compared with controls. Positive significant correlations were found between serum levels of YKL40 and patients’ age (r=0.588, p=0.001), duration of erectile dysfunction (r=0.673, p=0.001), BMI (r=0.598, p=0.001). The patients with hypertension had significantly elevated YKL-40 levels than those who were normotensive (164.88 ± 191.73 Vs 60.22 ± 26.44, respectively).
Conclusion: Serum levels of YKL-40 are elevated in arteriogenic ED patients denoting that endothelial dysfunction play a role in the pathogenesis of arteriogenic ED and YKL-40 as a novel marker of endothelial dysfunction could be a marker of arteriogenic erectile dysfunction.
Keywords
Arteriogenic; ED; endothelial dysfunction; YKL-40
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